SP1 In-Cell ELISA

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SKU:
CBCAB01207
€499

Description

SP1 Cell-Based ELISA

Product Description:The SP1 Colorimetric Cell-Based ELISA allows for qualitative detection of SP1 in plated and fixed cells.
Target Synonyms:Transcription factor SP1; transcription factor Sp1; TSFP1
Detection Target:Phospho-IRAK1(Thr209)
Reactivity:H, M, R
Pack Size:1 x 96 assays
Detection Method:Colorimetric 450 nm
Format:Cell-Based ELISA/In-Cell ELISA
Storage and Stability Guarantee:4°C/6 Months
Sample Type:Plated & fixed cells
Range:5000 cells/well minimum
Time:4.5 hours

SP1 Cell-Based ELISA Protein Information

UniProt Protein Function:SP1: a transcription factor of the Sp1 C2H2-type zinc-finger protein family. Phosphorylated and activated by MAPK. Dephosphorylation by PTEN inhibits DNA binding. Binds to p38 in the nucleus. Interacts with Huntingtin and TAFII130. Transcriptional activity of SP1 and TAFII130 disrupted in early Huntingtin's Disease.
UniProt Protein Details:

Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function:protein C-terminus binding; histone acetyltransferase binding; protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; metal ion binding; histone deacetylase binding; double-stranded DNA binding; bHLH transcription factor binding; transcription factor binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; embryonic placenta development; ossification; transcription, DNA-dependent; viral reproduction; megakaryocyte differentiation; positive regulation of transcription, DNA-dependent; embryonic skeletal development; embryonic process involved in female pregnancy; rhythmic process; cellular lipid metabolic process; enucleate erythrocyte differentiation; liver development; trophectodermal cell differentiation; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; lung development

NCBI Summary:The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
UniProt Code:P08047
NCBI GenInfo Identifier:13638437
NCBI Gene ID:6667
NCBI Accession:P08047.3
UniProt Secondary Accession:P08047,Q86TN8, Q9H3Q5, Q9NR51, Q9NY21, Q9NYE7, E4Z9M7 G5E9M8,
UniProt Related Accession:P08047
Molecular Weight:
NCBI Full Name:Transcription factor Sp1
NCBI Synonym Full Names:Sp1 transcription factor
NCBI Official Symbol:SP1  
NCBI Protein Information:transcription factor Sp1; specificity protein 1
UniProt Protein Name:Transcription factor Sp1
Protein Family:Sex-specific storage-protein
UniProt Gene Name:SP1  
UniProt Entry Name:SP1_HUMAN
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