TMPO
TMPO (thymopoietin) is a LEM domain containing protein of the nucleus, also known as TP, LAP2 and LEMD4. The gene encodes several isoforms through alternative splicing, and the alpha isoform is annotated as lamina-associated polypeptide 2, isoform alpha. Browse Assay Genie's current range of TMPO research reagents below, or read on for the biology behind the target.
TMPO belongs to the LEM family. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and they are involved in a range of cellular functions including gene expression, chromatin organisation, replication and cell cycle control. The distinct TMPO isoforms may compete with one another when acting to chaperone other proteins and regulate transcription.
The TMPO gene encodes several distinct isoforms through alternative splicing. The alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain. The beta and gamma isoforms are instead localised to the nuclear membrane and contain an HDAC3 interaction domain. UniProt lists the TMPO protein as being found in the nucleus and on chromosomes, and its alpha isoform is named lamina-associated polypeptide 2, isoform alpha.
The name thymopoietin reflects an immunological annotation. UniProt states that TP and TP5 may play a role in T-cell development and function, and describes TP5 as an immunomodulating pentapeptide. Aliases for the gene include TP, LAP2 and LEMD4, and HGNC places it in the LEM domain containing gene group. Mouse and rat both carry a Tmpo ortholog, which allows the gene to be studied in common model organisms.
The alpha isoform carries a lamin binding domain, making TMPO relevant to work on how LEM domain proteins connect to the nuclear lamina.
LEM domain proteins contribute to chromatin organisation and gene expression, and TMPO isoforms may chaperone proteins and regulate transcription.
LEM domain proteins are involved in replication and cell cycle control, placing TMPO within studies of nuclear function during cell division.
UniProt notes that TP and TP5 may play a role in T-cell development and function, linking TMPO to immunomodulation research.
TMPO is a LEM domain protein involved in nuclear functions such as gene expression, chromatin organisation, replication and cell cycle control. Its isoforms may compete when chaperoning other proteins and regulating transcription. UniProt also notes that TP and TP5 may play a role in T-cell development and function.
TMPO stands for thymopoietin and is also known as TP, LAP2 and LEMD4. Alternative splicing yields several isoforms. The alpha isoform is diffuse in the nucleus with a lamin binding domain, while beta and gamma localise to the nuclear membrane and have an HDAC3 interaction domain.
Yes, mouse and rat each have an ortholog named Tmpo, so the gene can be studied in common rodent models. Isoform composition and reactivity can differ between species, so check the datasheet of any product for its validated reactivity.
Other LEM domain proteins, nuclear lamina components and chromatin regulators related to TMPO.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P42166; product specifications from Assay Genie datasheets.