URI1
URI1 (URI1 prefoldin like chaperone, also known as unconventional prefoldin RPB5 interactor 1, RMP, URI, NNX3 and PPP1R19) is a scaffolding protein of the prefoldin family. It helps maintain S6K1 signalling and links nutrient-sensitive transcription to mTOR. Browse Assay Genie's current range of URI1 research reagents below, or read on for the biology behind the target.
URI1 acts as a scaffolding protein. It is able to assemble a prefoldin-like complex that contains prefoldin subunits together with proteins that have roles in transcription and ubiquitination. Part of this activity comes from its interaction with RPB5, a subunit of RNA polymerase II, which gives the protein its UniProt name, unconventional prefoldin RPB5 interactor 1.
The protein also has a defined role in signalling. Under normal growth conditions, URI1 maintains S6K1 signalling and BAD phosphorylation, which protects cells from the harmful effects of sustained S6K1 signalling. The URI1-PPP1CC complex forms a central part of a negative feedback mechanism that counteracts excessive S6K1 survival signalling to BAD in response to growth factors. In mitochondria, URI1 mediates inhibition of PPP1CC phosphatase activity. It also coordinates the availability of nutrient-sensitive gene expression in an mTOR-dependent manner.
The URI1 gene encodes a member of the prefoldin family of molecular chaperones and belongs to the RNA polymerase II subunit 5-mediating protein family. HGNC places it among the protein phosphatase 1 regulatory subunits, prefoldin subunits and the prefoldin-like complex. UniProt reports the protein in the nucleus, cytoplasm, mitochondrion and dendrites. Earlier names include chromosome 19 open reading frame 2 (C19orf2). NCBI Gene notes that URI1 may play a role in several malignancies, including ovarian cancer and hepatocellular carcinoma, and that alternative splicing produces multiple isoforms. A pseudogene lies on the long arm of chromosome 22. The mouse ortholog is Uri1.
URI1 helps maintain S6K1 signalling and BAD phosphorylation, and links nutrient-sensitive gene expression to mTOR.
The URI1-PPP1CC complex forms a negative feedback loop that limits excessive S6K1 survival signalling to BAD.
URI1 scaffolds a prefoldin-like complex with transcription and ubiquitination proteins, partly through RNA polymerase II subunit RPB5.
The URI1 gene may play a role in several malignancies, including ovarian cancer and hepatocellular carcinoma.
URI1 is a scaffolding protein. It maintains S6K1 signalling and BAD phosphorylation under normal growth conditions, and with PPP1CC it forms a negative feedback loop on S6K1 survival signalling. It also assembles a prefoldin-like complex and coordinates nutrient-sensitive gene expression in an mTOR-dependent manner.
URI1 is also called RMP, NNX3, URI, PPP1R19, FLJ10575 and C19orf2, the last from the earlier name chromosome 19 open reading frame 2. UniProt calls it unconventional prefoldin RPB5 interactor 1. NCBI Gene notes that alternative splicing gives multiple isoforms.
NCBI Gene reports that URI1 may play a role in multiple malignancies, including ovarian cancer and hepatocellular carcinoma. A mouse ortholog, Uri1, exists. Check the datasheet of any product for its validated reactivity.
Related targets and pathway partners for URI1 research, including mTOR and S6K1 signalling components.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O94763; product specifications from Assay Genie datasheets.