GPC5
GPC5 (glypican 5) is a cell surface proteoglycan that bears heparan sulfate and belongs to the glypican family. It is anchored to the plasma membrane through a glycosyl phosphatidylinositol linkage and is also found in the extracellular space. Browse Assay Genie's current range of GPC5 research reagents below, or read on for the biology behind the target.
GPC5 is a cell surface proteoglycan that bears heparan sulfate. Cell surface heparan sulfate proteoglycans are built from a membrane-associated protein core substituted with a variable number of heparan sulfate chains. GPC5 belongs to the glypican-related integral membrane proteoglycan family (GRIPS), whose members have a core protein anchored to the cytoplasmic membrane through a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
UniProt lists the subcellular location of Glypican-5 as the cell membrane and as secreted into the extracellular space. The human GPC5 gene is classified by HGNC in the glypican group, alongside related genes such as GPC1, GPC2, GPC4 and GPC6, and also in the group of microRNA protein coding host genes. The mouse ortholog is Gpc5.
Researchers studying the GPC5 gene and Glypican-5 protein are typically interested in heparan sulfate proteoglycan biology at the cell surface, and in how glypican family members relate to cell division and growth regulation. Comparing GPC5 with other glypicans helps place its role within the family.
GPC5 is a cell surface proteoglycan bearing heparan sulfate chains on a membrane-associated core protein, making it a subject for studies of proteoglycan structure.
Glypican family members may play a role in the control of cell division and growth regulation, a context in which GPC5 is studied.
GPC5 is anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage and is also found secreted in the extracellular space.
GPC5 sits in the glypican gene group with GPC1, GPC2, GPC4 and GPC6, allowing comparative work across the family.
GPC5 is a cell surface proteoglycan that bears heparan sulfate. As a member of the glypican-related integral membrane proteoglycan family, it may play a role in the control of cell division and growth regulation, according to the NCBI Gene summary.
GPC5 is the HGNC symbol for glypican 5, and UniProt names the protein Glypican-5. No alternative aliases or previous symbols are recorded in the data used here. It belongs to the glypican family and the HGNC glypican gene group.
A mouse ortholog, Gpc5, is recorded for the human GPC5 gene. A rat ortholog is not given in the data used here. Check the datasheet of any product for its validated reactivity.
Other glypican family members and heparan sulfate proteoglycans with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P78333; product specifications from Assay Genie datasheets.