IGBP1
IGBP1 (immunoglobulin binding protein 1, also known as α4 or IBP1) is a cytoplasmic protein associated with the surface IgM receptor. It also regulates the protein phosphatases PP2A, PP4 and PP6 by protecting their catalytic subunits from degradation. Browse Assay Genie's current range of IGBP1 research reagents below, or read on for the biology behind the target.
IGBP1 is involved in regulating the catalytic activity of the phosphatases PP2A, PP4 and PP6. It does so by protecting their partially folded catalytic subunits from degradative polyubiquitination until those subunits associate with their regulatory subunits. In this way IGBP1 acts as a modulatory factor that helps keep newly made phosphatase catalytic subunits intact during assembly of the active enzyme complexes.
The protein was first identified through its link to the B-cell receptor. UniProt describes it as associated with the surface IgM receptor and as possibly involved in signal transduction. B-cell proliferation and differentiation depend on the B-cell antigen receptor (BCR) complex. When antigen binds specific B-cell receptors, tyrosine phosphorylation occurs through the BCR complex and leads to multiple signal transduction pathways. IGBP1 is a cytoplasmic protein and belongs to the IGBP1/TAP42 family.
The IGBP1 gene is assigned by HGNC to the group of protein phosphatase 2 modulatory subunits. Its name reflects its early description as immunoglobulin (CD79A) binding protein 1, and it is also known as α4 and IBP1. Mouse and rat orthologues are both designated Igbp1. Researchers studying IGBP1 typically work on phosphatase regulation, protein stability and B-cell signalling.
IGBP1 modulates the catalytic activity of PP2A, PP4 and PP6, making it a useful target for studying how these phosphatases are controlled.
IGBP1 shields partially folded phosphatase catalytic subunits from degradative polyubiquitination until regulatory subunits bind, a feature relevant to protein quality control.
IGBP1 is associated with the surface IgM receptor and may contribute to signal transduction downstream of the BCR complex.
B-cell proliferation and differentiation rely on BCR signalling, placing IGBP1 in the context of B-cell function and development.
IGBP1 helps regulate the phosphatases PP2A, PP4 and PP6. It protects their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. It is also associated with the surface IgM receptor and may be involved in signal transduction.
IGBP1 stands for immunoglobulin binding protein 1. It is also called α4 and IBP1, and its previous HGNC name was immunoglobulin (CD79A) binding protein 1. UniProt lists the protein as immunoglobulin-binding protein 1, a member of the IGBP1/TAP42 family.
Mouse and rat both have an orthologous gene named Igbp1. Check the datasheet of any product for its validated reactivity. The protein belongs to the IGBP1/TAP42 family, and HGNC classes it with protein phosphatase 2 modulatory subunits.
Phosphatase catalytic subunits, B-cell receptor components and related signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P78318; product specifications from Assay Genie datasheets.