IL17RB
IL17RB (interleukin 17 receptor B, also known as IL17BR, IL17RH1, EVI27 and CRL4) is a cytokine receptor for the pro-inflammatory cytokines IL-17B and IL-17E. It is a member of the interleukin receptor gene group. Browse Assay Genie's current range of IL17RB research reagents below, or read on for the biology behind the target.
IL17RB is a receptor for the pro-inflammatory cytokines IL-17B and IL-17E (also called IL-25). NCBI Gene reports that it binds these two ligands specifically and does not bind IL-17 or IL-17C. This selectivity distinguishes it from other members of the IL-17 signalling network. Signalling through the receptor has been shown to mediate activation of NF-kappaB and the production of IL-8 induced by IL-17E. UniProt also notes that it may play a role in controlling the growth and/or differentiation of haematopoietic cells.
The human IL17RB gene encodes a protein annotated in UniProt as localised to the cell membrane and also as secreted. The gene sits in the HGNC interleukin receptors group. Researchers working on the pathway may encounter the protein under several names, including IL17BR, IL17RH1, EVI27 and CRL4. The previous HGNC name was interleukin 17B receptor. A mouse ortholog, Il17rb, is recorded for the gene, which is useful for comparative and in vivo work.
On disease relevance, NCBI Gene notes that expression of the rat counterpart of this gene was significantly up-regulated during intestinal inflammation. This suggests that the receptor has immunoregulatory activity. For anyone studying the IL-17B and IL-17E axis, the IL17RB protein is a key point for examining how these cytokines trigger NF-kappaB and IL-8 responses.
IL17RB binds IL-17B and IL-17E but not IL-17 or IL-17C, making it a defined entry point for studying ligand selectivity in the IL-17 network.
The receptor mediates NF-kappaB activation and IL-8 production induced by IL-17E, so it is relevant to downstream inflammatory signalling studies.
Rat IL17RB expression was significantly up-regulated during intestinal inflammation, pointing to an immunoregulatory role worth examining in gut models.
UniProt notes that IL17RB may control the growth and differentiation of haematopoietic cells, supporting studies of cytokine receptor function in these lineages.
IL17RB is a cytokine receptor for IL-17B and IL-17E. It has been shown to mediate NF-kappaB activation and IL-8 production induced by IL-17E. UniProt also suggests it may help control the growth and differentiation of haematopoietic cells.
The HGNC name is interleukin 17 receptor B. Aliases and previous symbols include IL17BR, IL17RH1, EVI27 and CRL4, and an earlier name was interleukin 17B receptor. UniProt lists the protein as interleukin-17 receptor B, found at the cell membrane and in secreted form.
A mouse ortholog, Il17rb, is recorded for the gene. NCBI Gene reports that expression of the rat counterpart rose significantly during intestinal inflammation, suggesting an immunoregulatory role. Check the datasheet of any product for its validated reactivity.
Ligands, other IL-17 family cytokines and related interleukins relevant to IL17RB signalling research, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NRM6; product specifications from Assay Genie datasheets.