LILRA4
LILRA4 (leukocyte immunoglobulin like receptor A4, also known as ILT7 or CD85g) is an immunoglobulin-like cell surface receptor expressed predominantly on plasmacytoid dendritic cells. It acts as a coreceptor that limits innate immune responses to viral infection. Browse Assay Genie's current range of LILRA4 research reagents below, or read on for the biology behind the target.
LILRA4 functions as a coreceptor that limits innate immune responses to viral infections, with signalling occurring via FCER1G. In complex with FCER1G it activates a signalling cascade that results in phosphorylation of Src family and Syk kinases and triggers mobilisation of intracellular Ca(2+). Despite this activating machinery, its net effect in plasmacytoid dendritic cells is inhibitory.
In plasmacytoid dendritic cells exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, LILRA4 down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF. This indicates that it is a negative regulator of TLR7 and TLR9 signalling cascades. It also down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. It does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.
The LILRA4 gene encodes an immunoglobulin-like cell surface protein expressed predominantly on plasmacytoid dendritic cells, where it modulates their function in the immune response. Its expression is downregulated by interleukin 3 (IL3). The gene is one of a cluster of highly related genes, and HGNC places it among the CD molecules and the activating leukocyte immunoglobulin like receptors. Its previous HGNC name was leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4.
LILRA4 is expressed predominantly on plasmacytoid dendritic cells and modulates their function, making it a useful marker and regulator for studying this cell type.
LILRA4 limits innate responses to viral infection, including interferon production in response to influenza virus and HIV-1 infected cells.
As a negative regulator of TLR7 and TLR9 cascades, LILRA4 helps define how type I interferon and TNF output is controlled.
LILRA4 signals through FCER1G to drive Src family and Syk kinase phosphorylation and intracellular Ca(2+) mobilisation.
LILRA4 is a coreceptor on plasmacytoid dendritic cells that limits innate immune responses to viral infection. It signals via FCER1G, activating Src family and Syk kinases and Ca(2+) mobilisation, yet down-regulates interferon and TNF production by acting as a negative regulator of TLR7 and TLR9 signalling.
LILRA4 is also known as ILT7 and CD85g. The UniProt protein name is leukocyte immunoglobulin-like receptor subfamily A member 4, and an earlier HGNC name was leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4.
The LILRA4 gene is one of a cluster of highly related genes at chromosomal region 19q13.4. HGNC classes it with the activating leukocyte immunoglobulin like receptors, alongside LILRA1, LILRA2, LILRA3 and LILRA5. Check the datasheet of any product for its validated reactivity.
Other activating leukocyte immunoglobulin like receptors from the same gene cluster.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P59901; product specifications from Assay Genie datasheets.