TACC1
TACC1 (transforming acidic coiled-coil containing protein 1) is a member of the TACC family that has been linked to transcription regulation by nuclear receptors and to the cell division that precedes tissue differentiation. The TACC1 gene lies close to FGFR1 in a region of chromosome 8 amplified in some breast cancers. Browse Assay Genie's current range of TACC1 research reagents below, or read on for the biology behind the target.
TACC1 is involved in transcription regulation induced by nuclear receptors, including the T3 thyroid hormone and all-trans retinoic acid pathways. It might promote the nuclear localisation of these receptors. TACC1 is also likely to participate in the processes that promote cell division before differentiated tissues form, which makes it a point of interest for researchers studying proliferation and development.
The TACC1 protein belongs to the TACC family, the HGUC gene group that also includes TACC2 and TACC3. UniProt records its subcellular locations as the cytoplasm, the nucleus, the centrosome within the cytoskeleton's microtubule organising centre, the midbody and membranes. This spread of locations is consistent with roles both in the nucleus and during cell division. Several transcript variants of the TACC1 gene encode different isoforms, so the isoform under study is worth defining in any experiment. The mouse ortholog is Tacc1.
The name reflects the protein's acidic, coiled-coil character and an earlier designation as a transforming protein. In NCBI Gene, the locus may represent a breast cancer candidate gene. It sits close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Together with its nuclear receptor connection, this gives TACC1 relevance to both transcription biology and cancer genetics.
TACC1 is implicated in transcription regulation by nuclear receptors, including the T3 thyroid hormone and all-trans retinoic acid pathways.
TACC1 is likely involved in processes that promote cell division before differentiated tissues form, and it localises to the centrosome and midbody.
The TACC1 locus is a breast cancer candidate, lying near FGFR1 in a chromosome 8 region amplified in some breast cancers.
TACC1 belongs to the TACC family, so it is often studied alongside TACC2 and TACC3 to compare family roles.
TACC1 is involved in transcription regulation induced by nuclear receptors, including the T3 thyroid hormone and all-trans retinoic acid pathways, and might promote nuclear localisation of the receptors. It is also likely involved in processes that promote cell division prior to the formation of differentiated tissues.
HGNC lists no aliases for TACC1. Its previous name was transforming, acidic coiled-coil containing protein 1. NCBI Gene reports that several transcript variants encode different isoforms, so check the datasheet of any product for its validated reactivity and the isoforms it recognises.
NCBI Gene notes that the locus may represent a breast cancer candidate gene, near FGFR1 in a chromosome 8 region amplified in some breast cancers. A mouse ortholog, Tacc1, exists. Check the datasheet of any product for its validated reactivity.
Other TACC family members with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75410; product specifications from Assay Genie datasheets.