CCN1
CCN1 (cellular communication network factor 1, also known as CYR61, GIG1 and IGFBP10) is a secreted, growth factor-inducible member of the CCN family. It promotes cell adhesion, proliferation, chemotaxis and angiogenesis through interactions with integrins and heparan sulfate proteoglycan. Browse Assay Genie's current range of CCN1 research reagents below, or read on for the biology behind the target.
CCN1 is a secreted protein that promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. It acts largely through integrins: adhesion and adhesive signalling are mediated by integrin alpha-6/beta-1, cell migration by integrin alpha-v/beta-5, and cell proliferation by integrin alpha-v/beta-3. The protein also interacts with heparan sulfate proteoglycan, and its effects on gene regulation depend on heparin-binding.
The protein appears to contribute to wound healing. In skin fibroblasts, CCN1 up-regulates a set of genes involved in angiogenesis, inflammation and matrix remodelling, including VEGF-A, VEGF-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and the integrin alpha-3 and alpha-5 subunits. At the same time it down-regulates expression of the alpha-1 and alpha-2 subunits of type I collagen. NCBI Gene also links the encoded protein to differentiation, apoptosis and extracellular matrix formation, and describes it as growth factor-inducible and able to promote endothelial cell adhesion.
The CCN1 gene belongs to the cellular communication network factor group, which is why the protein is classed within the CCN family. The symbol replaced the earlier name cysteine rich angiogenic inducer 61, from which the alias CYR61 derives; GIG1 and IGFBP10 are further names found in the literature. Because CCN1 sits at the junction of integrin signalling, angiogenesis and matrix remodelling, it is a frequent subject in studies of tissue repair and vascular biology.
CCN1 appears to drive wound repair by up-regulating angiogenic, inflammatory and matrix-remodelling genes in skin fibroblasts.
CCN1 promotes angiogenesis and endothelial cell adhesion, making it a relevant factor for investigating new vessel formation.
CCN1 engages integrins alpha-6/beta-1, alpha-v/beta-5 and alpha-v/beta-3 to direct adhesion, migration and proliferation.
CCN1 regulates MMP1, MMP3, TIMP1 and type I collagen expression, linking it to matrix turnover and extracellular matrix formation.
CCN1 is a secreted protein that promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. It signals through several integrins and binds heparan sulfate proteoglycan. In skin fibroblasts it appears to support wound healing by regulating genes for angiogenesis, inflammation and matrix remodelling.
CCN1 is the current HGNC symbol for cellular communication network factor 1. Earlier names and aliases include CYR61 (from cysteine rich angiogenic inducer 61), GIG1 and IGFBP10. UniProt lists the protein as CCN family member 1, so literature may use any of these terms.
Yes. CCN1 belongs to the CCN family, and a rat ortholog, Ccn1, is recorded for the human gene. Species relevance differs between experiments, so check the datasheet of any product for its validated reactivity.
Other CCN family members, integrins, matrix-remodelling enzymes and angiogenic factors connected to CCN1 biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00622; product specifications from Assay Genie datasheets.