CLDN7
CLDN7 (claudin 7) is an integral membrane protein of the claudin family and a component of tight junction strands. It plays a major role in tight junction-specific obliteration of the intercellular space, and is also known as CEPTRL2, CPETRL2 or Hs.84359. Browse Assay Genie's current range of CLDN7 research reagents below, or read on for the biology behind the target.
CLDN7 is a member of the claudin family of integral membrane proteins, which are components of tight junction strands. Tight junction strands act as a physical barrier that stops solutes and water passing freely through the paracellular space between epithelial or endothelial cell sheets. For Claudin-7 specifically, UniProt annotates a major role in tight junction-specific obliteration of the intercellular space. Tight junctions also contribute to maintaining cell polarity and to signal transduction.
Claudin-7 localises to the cell membrane, including the basolateral cell membrane, and to the cell junction at tight junctions. The CLDN7 gene encodes a protein of the claudin family, and alternatively spliced transcript variants encoding different isoforms have been reported. Researchers working with the CLDN7 gene or Claudin-7 protein often study it alongside other claudins, which together shape the selectivity and tightness of epithelial barriers.
Differential expression of CLDN7 has been observed in several types of malignancy, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumours, prostate cancer, lung cancer, head and neck cancers and thyroid carcinomas. This makes CLDN7 a frequent subject in studies of epithelial integrity and tumour biology. HGNC classifies the gene within the claudins group, and mouse and rat each carry a Cldn7 ortholog.
CLDN7 is a component of tight junction strands and contributes to obliteration of the intercellular space between adjacent cells.
Claudins form a physical barrier limiting passage of solutes and water through the paracellular space of epithelial and endothelial sheets.
Tight junction strands help maintain cell polarity and take part in signal transduction, placing CLDN7 in studies of junctional signalling.
Differential CLDN7 expression has been reported in breast, ovarian, liver, prostate, lung, thyroid, urinary and head and neck malignancies.
CLDN7 encodes claudin 7, an integral membrane protein found in tight junction strands. UniProt annotates a major role in tight junction-specific obliteration of the intercellular space. Tight junctions form a barrier to solutes and water in the paracellular space and support cell polarity and signal transduction.
CLDN7 is also called claudin 7 or Claudin-7, and has the aliases Hs.84359, CEPTRL2 and CPETRL2. NCBI Gene reports that alternatively spliced transcript variants encoding different isoforms have been found. Check the datasheet of any product for its validated reactivity.
Differential CLDN7 expression has been observed in malignancies including breast, ovarian, hepatocellular, urinary, prostate, lung, head and neck and thyroid cancers. Orthologs exist in mouse and rat, both named Cldn7. Check the datasheet of any product for its validated reactivity.
Other claudin family members and tight junction proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95471; product specifications from Assay Genie datasheets.