CTAG1B
CTAG1B (cancer/testis antigen 1B), also known as NY-ESO-1, is a cytoplasmic antigen that is overexpressed in many cancers but is also expressed in normal testis. It is also referred to as LAGE2B, LAGE2A, ESO1, CT6.1, CTAG and CTAG1. Browse Assay Genie's current range of CTAG1B research reagents below, or read on for the biology behind the target.
CTAG1B encodes cancer/testis antigen 1, an antigen that is overexpressed in many cancers but is also expressed in normal testis. This restricted pattern of expression is the defining feature of cancer/testis antigens and the reason the protein is widely discussed in tumour immunology. UniProt does not currently provide a curated functional annotation for the protein, and its subcellular location is listed as the cytoplasm.
The human CTAG1B gene sits on the X chromosome, and the NCBI Gene summary notes that it lies within a duplicated region of the X-chromosome. As a result, it has a neighbouring gene of identical sequence. This is reflected in the HGNC gene group, which describes the symbol as belonging to proteins encoded by multiple genes, and it is worth bearing in mind when interpreting gene-level data for CTAG1B. The protein belongs to the CTAG/PCC1 family.
The target is best known under the alias NY-ESO-1, and the literature also uses LAGE2B, LAGE2A, ESO1, CT6.1, CTAG and CTAG1 for the gene or its products. The previous HGNC name was simply cancer/testis antigen 1. Researchers studying the NY-ESO-1 antigen, whether through the CTAG1B gene or the expressed protein, should check which symbol a given reference uses, since the duplicated locus and the number of historical aliases can make records difficult to reconcile.
CTAG1B is an antigen overexpressed in many cancers, which makes it a recurring subject in studies of tumour-associated antigens.
The protein is also expressed in normal testis, so CTAG1B is relevant to work comparing tumour and germline-restricted expression.
As a member of the CTAG/PCC1 family, CTAG1B provides a reference point for studying how cancer/testis antigens are regulated and distributed.
The duplicated Xq28 region gives CTAG1B a neighbouring gene of identical sequence, a point of interest in genomic and expression analysis.
CTAG1B encodes cancer/testis antigen 1, also called NY-ESO-1. According to NCBI Gene, it is an antigen overexpressed in many cancers and also expressed in normal testis. UniProt gives no curated functional annotation, and the protein is localised to the cytoplasm.
CTAG1B is widely known as NY-ESO-1. Other aliases and previous symbols are LAGE2B, LAGE2A, ESO1, CT6.1, CTAG and CTAG1. The HGNC name is cancer/testis antigen 1B, and the earlier name was cancer/testis antigen 1.
NCBI Gene states that the gene is found in a duplicated region of the X-chromosome, so it has a neighbouring gene of identical sequence. HGNC groups it among proteins encoded by multiple genes. No mouse or rat ortholog is given in the data.
Other cancer/testis antigens and tumour-associated antigens with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P78358; product specifications from Assay Genie datasheets.