CKLF
CKLF (chemokine like factor, also known as UCK-1, CKLF1, CKLF3, CKLF4, HSPC224 and C32) is a cytokine with chemotactic activity towards neutrophils, monocytes and lymphocytes. It binds the chemokine receptor CCR4 and is linked to inflammation and skeletal muscle regeneration. Browse Assay Genie's current range of CKLF research reagents below, or read on for the biology behind the target.
CKLF is a cytokine, one of the small proteins that have an essential role in immune and inflammatory responses. It has a chemotactic effect on monocytes, neutrophils and lymphocytes, and is described as a potent chemoattractant for these cells. It binds CCR4, a chemokine receptor, which provides a route by which it can act on responding leukocytes. UniProt reports the protein in both secreted and membrane-associated forms.
Beyond leukocyte recruitment, the CKLF protein can stimulate the proliferation of skeletal muscle cells. For this reason it is thought to play roles both in inflammation and in the regeneration of skeletal muscle. The protein belongs to the chemokine-like factor family.
The CKLF gene is one of several chemokine-like factor genes found in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified, and naturally occurring read-through transcription takes place between this locus and the neighbouring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1). The protein was previously named chemokine-like factor 1, and the gene has also been recorded under the symbols UCK-1, CKLF1, CKLF3, CKLF4, HSPC224 and C32. Mouse and rat each have an orthologous Cklf gene.
CKLF is a cytokine involved in inflammatory responses and may play important roles in inflammation, making it relevant to studies of immune activation.
CKLF attracts neutrophils, monocytes and lymphocytes, so it is used to study how leukocytes are recruited and directed.
CKLF binds CCR4, making it a useful ligand for studying receptor engagement by chemokine-like factors.
CKLF can stimulate proliferation of skeletal muscle cells and may contribute to muscle regeneration, an area of interest in repair biology.
CKLF is a cytokine with chemotactic activity towards monocytes, neutrophils and lymphocytes, and it binds CCR4. It can also stimulate the proliferation of skeletal muscle cells, and it may have roles in inflammation and in skeletal muscle regeneration.
CKLF is also known as UCK-1, CKLF1, CKLF3, CKLF4, HSPC224 and C32, and was previously called chemokine-like factor 1. Alternatively spliced transcript variants encoding different isoforms have been identified. Read-through transcription also occurs between CKLF and the neighbouring CMTM1 locus.
Mouse and rat both have an orthologous gene named Cklf. In humans, CKLF sits in a cluster of chemokine-like factor genes on chromosome 16. Check the datasheet of any product for its validated reactivity.
Chemokine receptors, CKLF-like MARVEL transmembrane proteins and other chemotactic cytokines with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UBR5; product specifications from Assay Genie datasheets.