GP9
GP9 (glycoprotein IX platelet, also known as GPIX or CD42a) is a small membrane glycoprotein on the surface of human platelets. It is a component of the GPIb-V-IX complex, the receptor for von Willebrand factor (vWF). Browse Assay Genie's current range of GP9 research reagents below, or read on for the biology behind the target.
GP9 is part of the GPIb-V-IX complex, which functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. Adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in haemostasis. GP9 may provide for membrane insertion and orientation of GP-Ib, the subunit it partners with in the complex.
The GP9 gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib. The complete receptor complex includes noncovalent association of the alpha and beta subunits of glycoprotein Ib with the GP9 protein and platelet glycoprotein V. These partners are encoded by GP1BA, GP1BB and GP5. The mouse ortholog is Gp9.
Defects in the GP9 gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. Patients with this condition have unusually large platelets and a clinical bleeding tendency. HGNC classes GP9 among the CD molecules, and the protein is also referred to as CD42a. Its earlier HGNC name was glycoprotein IX (platelet). This makes GP9 a useful reference point for studies of platelet adhesion, receptor assembly and inherited platelet disorders.
GP9 belongs to the vWF receptor complex that mediates platelet adhesion to injured vascular surfaces, an initiating event in haemostasis.
The GPIb-V-IX complex supports vWF-dependent adhesion in the arterial circulation, making GP9 relevant to models of vascular injury and bleeding.
Defects in GP9 cause Bernard-Soulier syndrome, characterised by unusually large platelets and a bleeding tendency.
GP9 forms a 1-to-1 noncovalent complex with glycoprotein Ib and may support membrane insertion and orientation of GP-Ib.
GP9 is a subunit of the GPIb-V-IX complex, which acts as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. It may also provide for membrane insertion and orientation of GP-Ib. Check the datasheet of any product for its validated reactivity.
GP9 is also called GPIX and CD42a, and its UniProt name is platelet glycoprotein IX. HGNC previously listed it as glycoprotein IX (platelet). It belongs to the CD molecules gene group.
Yes. According to NCBI Gene, defects in GP9 are a cause of Bernard-Soulier syndrome, or giant platelet disease. Patients have unusually large platelets and a clinical bleeding tendency. The mouse counterpart is the Gp9 gene.
Other subunits of the GPIb-V-IX complex and related platelet glycoproteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P14770; product specifications from Assay Genie datasheets.