RLBP1
RLBP1 (retinaldehyde binding protein 1), also known as CRALBP, is a soluble cytoplasmic retinoid carrier that is essential for the proper function of both rod and cone photoreceptors. It carries 11-cis-retinaldehyde and 11-cis-retinol as part of the visual cycle. Browse Assay Genie's current range of RLBP1 research reagents below, or read on for the biology behind the target.
RLBP1 is a water-soluble retinoid carrier required for the proper function of rod and cone photoreceptors. It takes part in the regeneration of the active chromophores 11-cis-retinol and 11-cis-retinaldehyde from the inactive 11-trans products of the rhodopsin photocycle. It also contributes to the de novo synthesis of these retinoids from 11-trans metabolic precursors. The movement of retinoids between photoreceptors and the adjacent pigment epithelium cells is known as the visual cycle, and RLBP1 is considered a functional component of this process.
The RLBP1 gene encodes a protein of about 36 kD that carries 11-cis-retinaldehyde (11-cis-retinal) as a physiological ligand. UniProt annotates the protein as cytoplasmic. HGNC places it in the CRAL-TRIO lipid binding domain containing gene group, and the mouse ortholog is Rlbp1. The protein is also called CRALBP, a name derived from cellular retinaldehyde-binding protein, and HGNC lists the previous name as retinaldehyde-binding protein 1.
Mutations in the RLBP1 gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (a nonsyndromic autosomal recessive form of retinitis pigmentosa) and retinitis punctata albescens. This makes the protein a point of interest for researchers studying inherited retinal disease and retinoid handling in the visual cycle. Researchers working with an RLBP1 antibody, RLBP1 ELISA kit or recombinant RLBP1 protein typically do so in this context.
RLBP1 helps regenerate 11-cis-retinol and 11-cis-retinaldehyde, so it is a key protein for studying retinoid cycling between photoreceptors and pigment epithelium.
RLBP1 is essential for the proper function of both rod and cone photoreceptors, making it relevant to studies of phototransduction support.
RLBP1 mutations are linked to rod-cone dystrophy, Bothnia dystrophy and retinitis punctata albescens, providing a basis for disease mechanism studies.
As a soluble carrier of 11-cis-retinal, RLBP1 is used to examine how retinoid ligands are bound and delivered within cells.
RLBP1 is a soluble retinoid carrier needed for proper rod and cone function. It participates in regenerating 11-cis-retinol and 11-cis-retinaldehyde from inactive 11-trans products of the rhodopsin photocycle, and in their de novo synthesis from 11-trans precursors, within the visual cycle.
Yes. CRALBP is an alias for RLBP1, whose full name is retinaldehyde binding protein 1. HGNC also records the previous name retinaldehyde-binding protein 1. The two symbols refer to the same gene and protein, so literature searches should cover both.
Mutations in the RLBP1 gene are associated with severe rod-cone dystrophy, Bothnia dystrophy and retinitis punctata albescens. A mouse ortholog, Rlbp1, exists; check the datasheet of any product for its validated reactivity.
Other visual cycle proteins, retinoid-binding proteins and photoreceptor markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P12271; product specifications from Assay Genie datasheets.