ETS2
ETS2 (ETS proto-oncogene 2, transcription factor), also known as Protein C-ets-2, is a nuclear transcription factor of the ETS family. It binds the GGAA/T core motif in gene promoters and stimulates transcription of genes involved in development and apoptosis. Browse Assay Genie's current range of ETS2 research reagents below, or read on for the biology behind the target.
ETS2 is a transcription factor that activates transcription. It binds specifically to the GGAA/T core motif, known as the Ets-binding site or EBS, in gene promoters and stimulates transcription from those promoters. The protein is found in the nucleus, which fits its role as a regulator of gene expression. Researchers studying ETS2 often look at promoter occupancy, target gene activation and the way the protein is controlled within the cell.
According to the NCBI Gene summary, the ETS2 gene encodes a transcription factor that regulates genes involved in development and apoptosis. The encoded protein is also a proto-oncogene and has been shown to take part in the regulation of telomerase. This places the ETS2 protein at the meeting point of developmental programmes, cell survival control and cancer biology. The gene produces multiple transcript variants through alternative splicing, and a pseudogene of ETS2 is located on the X chromosome, which is worth bearing in mind when designing nucleic acid based assays.
ETS2 belongs to the ETS family of transcription factors, a group that also includes ETS1. The HGNC name for the gene is ETS proto-oncogene 2, transcription factor. Earlier names were v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) and v-ets avian erythroblastosis virus E26 oncogene homolog 2, which reflect the gene's origin as the cellular counterpart of a viral oncogene. The mouse ortholog is called Ets2.
ETS2 binds the GGAA/T Ets-binding site in gene promoters and stimulates transcription, making it a model for studying ETS family promoter control.
The ETS2 gene regulates genes involved in apoptosis, so the protein is relevant to studies of cell survival and cell death.
ETS2 regulates genes involved in development, which makes it a useful target for work on gene expression programmes during differentiation.
As a proto-oncogene implicated in telomerase regulation, ETS2 is studied in cancer biology and in the control of telomere maintenance.
ETS2 is a transcription factor that binds the GGAA/T core motif, the Ets-binding site, in gene promoters and stimulates transcription. It regulates genes involved in development and apoptosis, and it has been shown to take part in the regulation of telomerase.
The HGNC name is ETS proto-oncogene 2, transcription factor, and UniProt lists the protein as Protein C-ets-2. Earlier names were v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) and v-ets avian erythroblastosis virus E26 oncogene homolog 2. Alternative splicing gives multiple transcript variants.
The mouse has an ortholog named Ets2. ETS2 is described as a proto-oncogene, so it is of interest in cancer research. Check the datasheet of any product for its validated reactivity before using it in a particular species.
ETS1 and other ETS family transcription factors with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P15036; product specifications from Assay Genie datasheets.