TMED1
TMED1 (transmembrane p24 trafficking protein 1, also known as p24gamma1, p24g1, ST2L and IL1RL1LG) is a member of the EMP24/GP25L family involved in vesicular protein trafficking. It acts mainly in the early secretory pathway and also contributes to innate immune signalling. Browse Assay Genie's current range of TMED1 research reagents below, or read on for the biology behind the target.
TMED1 has a potential role in vesicular protein trafficking, mainly in the early secretory pathway. It may act as a cargo receptor on the lumenal side, helping to incorporate secretory cargo molecules into transport vesicles, and may also be involved in vesicle coat formation on the cytoplasmic side. Consistent with this, UniProt places the protein in the cell membrane, the endoplasmic reticulum membrane, the cis-Golgi network membrane and the endoplasmic reticulum-Golgi intermediate compartment membrane.
Beyond trafficking, TMED1 has roles in immune signalling. It plays a positive role in IL-33-mediated production of IL-8 and IL-6 by interacting with the interleukin-33 receptor IL1RL1. It also modulates innate immune signalling through the cGAS-STING pathway by interacting with RNF26. The NCBI Gene summary notes that the protein was first identified through its interaction with IL1RL1 (interleukin 1 receptor-like 1) and that it lacks similarity to other interleukin 1 ligands. This history explains aliases such as ST2L and IL1RL1LG.
The TMED1 gene belongs to the TMED (transmembrane emp24 domain-containing) family, which HGNC groups as the transmembrane p24 trafficking proteins. Alternative splicing produces multiple transcript variants. Earlier names include transmembrane emp24 domain containing 1 and transmembrane emp24 protein transport domain containing 1. Orthologues are annotated in mouse and rat as Tmed1, so studies of TMED1 protein function can be carried out in common rodent models.
TMED1 is proposed to act as a cargo receptor and in vesicle coat formation, making it relevant to studies of early secretory pathway transport.
The protein is linked to innate immunity and modulates cGAS-STING signalling through its interaction with RNF26.
TMED1 positively influences IL-33-driven IL-8 and IL-6 production through its interaction with the IL-33 receptor IL1RL1.
Localisation to ER, ERGIC and cis-Golgi membranes as well as the cell membrane makes TMED1 useful for studying trafficking between compartments.
TMED1 has a potential role in vesicular protein trafficking in the early secretory pathway, where it may act as a cargo receptor and take part in vesicle coat formation. It also promotes IL-33-mediated IL-8 and IL-6 production via IL1RL1 and modulates cGAS-STING signalling through RNF26.
TMED1 is also known as p24gamma1, p24g1, ST2L, IL1RL1LG, Il1rl1l and MGC1270. Earlier names include transmembrane emp24 domain containing 1. The IL1RL1-related aliases reflect its identification through interaction with interleukin 1 receptor-like 1. Alternative splicing gives multiple transcript variants.
Yes. Mouse and rat both have an orthologous gene called Tmed1. TMED1 belongs to the EMP24/GP25L family, which HGNC groups with the transmembrane p24 trafficking proteins. Check the datasheet of any product for its validated reactivity.
Related receptors, innate immune signalling proteins and cytokines connected to TMED1 function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13445; product specifications from Assay Genie datasheets.