IGF-2
IGF-2 (insulin-like growth factor 2, also known as IGF-II) is a secreted polypeptide growth factor of the insulin family that is involved in development and growth. It is encoded by the imprinted IGF2 gene, which is expressed only from the paternal allele. Browse Assay Genie's current range of IGF-2 research reagents below, or read on for the biology behind the target.
IGF-2 belongs to the insulin family of polypeptide growth factors, which are involved in development and growth. The protein is secreted. UniProt annotates a peptide derived from the precursor, preptin, which undergoes glucose-mediated co-secretion with insulin and acts as a physiological amplifier of glucose-mediated insulin secretion. Preptin also shows osteogenic properties, increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
The IGF2 gene sits at 11p15.5 and is imprinted, so it is expressed only from the paternal allele. Alternatively spliced transcript variants encoding different isoforms have been described. A read-through gene, INS-IGF2, also exists; its 5' region overlaps the INS gene and its 3' region overlaps the IGF-2 gene. HGNC places the gene in the insulin family, and also in the groups of microRNA protein coding host genes and neuropeptides.
Because of imprinting, epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma and Silver-Russell syndrome. The gene has also been listed as C11orf43 and FLJ44734, and the protein is commonly written IGF-II. Mouse and rat each carry an orthologous Igf2 gene, which allows the biology to be studied in common model species.
IGF-2 is a member of the insulin family of polypeptide growth factors involved in development and growth, making it a core subject in developmental biology.
IGF2 is expressed only from the paternal allele, so it serves as a classic model for studying imprinting and its epigenetic regulation.
Epigenetic changes at the IGF2 locus are associated with Wilms tumour, rhabdomyosarcoma, Beckwith-Wiedemann syndrome and Silver-Russell syndrome.
The IGF-2 derived peptide preptin amplifies glucose-mediated insulin secretion and increases osteoblast mitogenic activity via MAPK1 and MAPK3 phosphoactivation.
IGF-2 is a secreted polypeptide growth factor of the insulin family involved in development and growth. A peptide derived from it, preptin, is co-secreted with insulin in response to glucose and amplifies insulin secretion. Preptin also increases osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
The protein is also written IGF-II, and the gene has carried the aliases FLJ44734 and C11orf43 (chromosome 11 open reading frame 43). NCBI Gene reports alternatively spliced transcript variants encoding different isoforms, plus a read-through INS-IGF2 gene that overlaps both INS and IGF2.
IGF2 is imprinted and expressed only from the paternal allele. Epigenetic changes at the locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma and Silver-Russell syndrome. Mouse and rat both have an Igf2 ortholog; check the datasheet of any product for its validated reactivity.
Other insulin-like growth factors, IGF-binding proteins and IGF2 mRNA-binding proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P01344; product specifications from Assay Genie datasheets.