LRPAP1
LRPAP1 (LDL receptor related protein associated protein 1), also known as RAP, HBP44, Alpha-2-MRAP and A2MRAP, is a molecular chaperone for LDL receptor-related proteins. It may regulate their ligand binding activity along the secretory pathway. Browse Assay Genie's current range of LRPAP1 research reagents below, or read on for the biology behind the target.
LRPAP1 acts as a molecular chaperone for LDL receptor-related proteins. It interacts with the LDL receptor-related protein and facilitates its proper folding and localisation by preventing the binding of ligands. In this way LRPAP1 may regulate the ligand binding activity of these receptors as they travel along the secretory pathway.
The LRPAP1 protein is found in several compartments of the secretory and endocytic routes: the lumen of the rough endoplasmic reticulum, the endoplasmic reticulum-Golgi intermediate compartment, the cis-Golgi network and Golgi lumen, and the endosome lumen. It is also reported at the cell surface. It belongs to the alpha-2-MRAP family. Alternative splicing of the LRPAP1 gene results in multiple transcript variants.
The name reflects its history. The protein was first described as the alpha-2-macroglobulin receptor-associated protein, which gives the aliases Alpha-2-MRAP, A2MRAP and RAP. Earlier gene names include low density lipoprotein-related protein-associated protein 1. Mutations in the LRPAP1 gene have been identified in individuals with myopia 23. Mouse and rat orthologs are both designated Lrpap1.
LRPAP1 facilitates the proper folding and localisation of LDL receptor-related protein, making it a model for studying receptor maturation.
As a chaperone that may regulate ligand binding along the secretory pathway, LRPAP1 is relevant to how receptors avoid premature ligand engagement.
LRPAP1 prevents ligand binding to LDL receptor-related proteins, so it is useful for investigating receptor-ligand interactions.
Mutations in the LRPAP1 gene have been identified in individuals with myopia 23, linking the protein to this inherited condition.
LRPAP1 is a molecular chaperone for LDL receptor-related proteins. It binds the LDL receptor-related protein, helps it fold and reach the correct location, and prevents ligand binding. It may thereby regulate the ligand binding activity of these receptors along the secretory pathway.
LRPAP1 is also called RAP, HBP44, Alpha-2-MRAP and A2MRAP. UniProt lists the protein as alpha-2-macroglobulin receptor-associated protein. Earlier gene names include low density lipoprotein-related protein-associated protein 1. Alternative splicing gives multiple transcript variants.
Mutations in the LRPAP1 gene have been identified in individuals with myopia 23. Orthologs exist in mouse and rat, both named Lrpap1, so rodent models can be used to study it. Check the datasheet of any product for its validated reactivity.
Other LDL receptor family members and chaperone-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P30533; product specifications from Assay Genie datasheets.