CXADR
CXADR (CXADR cell adhesion molecule, also known as CAR) is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. It is a member of the V-set domain containing IgCAM CXADR-related subfamily. Browse Assay Genie's current range of CXADR research reagents below, or read on for the biology behind the target.
CXADR, the coxsackievirus and adenovirus receptor, is a type I membrane receptor. Its best-characterised role in the source annotation is in viral infection: it acts as a receptor for coxsackieviruses B1 to B6, and the NCBI Gene summary also describes it as a receptor for subgroup C adenoviruses. Researchers therefore use the CXADR protein as a model for how viruses engage host cell-surface molecules.
UniProt places CXADR at the cell membrane, including the basolateral cell membrane, and at cell junctions, specifically tight junctions and adherens junctions. A secreted form is also recorded. This localisation is consistent with its classification as a cell adhesion molecule. HGNC assigns the CXADR gene to the V-set domain containing group and to the IgCAM CXADR-related subfamily. Several transcript variants encoding different isoforms have been reported for the gene, so studies of CXADR expression should take isoform diversity into account.
The official gene name has changed over time. Earlier HGNC names were coxsackie virus and adenovirus receptor and CXADR, Ig-like cell adhesion molecule, and the symbol CAR remains in common use as an alias. Pseudogenes of CXADR are found on chromosomes 15, 18 and 21, which is worth remembering when designing nucleic acid-based assays. Mouse and rat each have a Cxadr ortholog, allowing comparative work in rodent models.
CXADR acts as a receptor for coxsackieviruses B1 to B6, making it central to studies of how these viruses attach to and enter cells.
CXADR is a receptor for subgroup C adenoviruses, so it is relevant to research on adenovirus binding and host cell tropism.
CXADR localises to tight junctions and adherens junctions, supporting work on epithelial adhesion and junction composition.
Multiple transcript variants and pseudogenes on several chromosomes make CXADR a useful subject for isoform-specific expression studies.
CXADR is a type I membrane receptor. It serves as a receptor for group B coxsackieviruses (B1 to B6) and subgroup C adenoviruses. UniProt also places it at the cell membrane, tight junctions and adherens junctions, consistent with a cell adhesion molecule.
CXADR is commonly called CAR. Earlier HGNC names were coxsackie virus and adenovirus receptor, and CXADR, Ig-like cell adhesion molecule. The current name is CXADR cell adhesion molecule. Several transcript variants encode different isoforms, so literature may describe more than one form.
Yes. Mouse and rat both have an ortholog named Cxadr, which allows comparative studies in rodent systems. Researchers should check the datasheet of any product for its validated reactivity before use in a given species.
Other cell adhesion molecules and viral receptor targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P78310; product specifications from Assay Genie datasheets.