TCIRG1
TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3) is the a3 subunit of the V0 membrane complex of vacuolar H+-ATPase, a proton pump that acidifies cellular compartments. It is also known as TIRC7, OC-116, ATP6N1C, Atp6i and ATP6V0A3. Browse Assay Genie's current range of TCIRG1 research reagents below, or read on for the biology behind the target.
TCIRG1 is a subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase). This multisubunit enzyme has two parts: a peripheral V1 complex that hydrolyses ATP, and a membrane-integral V0 complex that translocates protons. By moving protons across the membrane, V-ATPase acidifies and maintains the pH of intracellular compartments. In some cell types it is targeted to the plasma membrane, where it acidifies the extracellular environment.
V-ATPase-dependent organelle acidification is necessary for intracellular processes including protein sorting, zymogen activation and receptor-mediated endocytosis. The TCIRG1 protein belongs to the V-ATPase 116 kDa subunit family and is annotated as a membrane protein. UniProt also notes that it seems to be directly involved in T-cell activation. The TCIRG1 gene undergoes alternative splicing, which produces multiple transcript variants.
The many names for this target reflect its history. Its HGNC name refers to a T cell immune regulator, while aliases such as TIRC7 and OC-116 and the symbols ATP6N1C, Atp6i and ATP6V0A3 appear in older literature and databases. HGNC places the gene in the V-type ATPase subunits group and also lists it among microRNA protein coding host genes. Mutations in the TCIRG1 gene are associated with infantile malignant osteopetrosis, which makes the protein a point of interest in bone biology as well as in proton-pump and immune research.
TCIRG1 is a V0 subunit of the proton pump that acidifies intracellular compartments and maintains their pH.
Mutations in the TCIRG1 gene are associated with infantile malignant osteopetrosis, making it a focus for studies of this disorder.
UniProt notes that TCIRG1 seems to be directly involved in T-cell activation, linking proton-pump biology to immune regulation.
V-ATPase-dependent acidification underlies protein sorting, zymogen activation and receptor-mediated endocytosis, processes in which TCIRG1 participates as a pump subunit.
TCIRG1 is a subunit of the V0 complex of V-ATPase, the membrane-integral part that translocates protons. The pump acidifies intracellular compartments and, in some cell types, the extracellular environment. UniProt also notes that it seems to be directly involved in T-cell activation.
Aliases include TIRC7, OC-116, OC116, ATP6N1C, Atp6i, a3 and ATP6V0A3. The UniProt protein name is V-type proton ATPase 116 kDa subunit a 3. NCBI notes that alternative splicing of the TCIRG1 gene gives multiple transcript variants.
Yes. NCBI Gene reports that mutations in the TCIRG1 gene are associated with infantile malignant osteopetrosis. Because the protein is part of the V-ATPase proton pump, this link connects acidification biology to bone disease. Check the datasheet of any product for its validated reactivity.
Other V-ATPase subunits and proton-pump components that may be of interest alongside TCIRG1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13488; product specifications from Assay Genie datasheets.