CACYBP
CACYBP (calcyclin binding protein, also known as SIP and S100A6BP) is a nuclear and cytoplasmic protein linked to calcium-dependent ubiquitination. It probably acts as a molecular bridge in ubiquitin E3 complexes and takes part in the degradation of beta-catenin. Browse Assay Genie's current range of CACYBP research reagents below, or read on for the biology behind the target.
CACYBP is thought to be involved in calcium-dependent ubiquitination and the subsequent proteasomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes, linking components of the machinery that tags substrates for destruction. The best-described substrate in the source annotation is beta-catenin (CTNNB1), whose ubiquitin-mediated degradation CACYBP participates in.
The human CACYBP gene encodes a protein of 228 amino acids that localises to the nucleus and the cytoplasm. The gene is conserved in other mammals, with orthologues named Cacybp in both mouse and rat, which allows the protein to be studied in common rodent models. According to the NCBI Gene summary, two alternatively spliced transcript variants have been found, and these encode different isoforms.
The name reflects the protein's identification as a binding partner of calcyclin, which is also known as S100A6; this explains the alias S100A6BP. The other alias, SIP, appears alongside it in gene databases. Because the annotation describes a role in calcium-dependent ubiquitination and in beta-catenin turnover, CACYBP is a useful target for researchers studying protein degradation, calcium signalling and the regulation of beta-catenin levels. Researchers working with a CACYBP antibody, CACYBP ELISA kit or recombinant CACYBP protein should consider the nuclear and cytoplasmic distribution of the protein when designing experiments.
CACYBP is proposed to bridge ubiquitin E3 complexes, making it relevant to studies of how target proteins are ubiquitinated and degraded.
CACYBP participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1), a link that is useful for studying control of beta-catenin protein levels.
The annotated role in calcium-dependent ubiquitination connects CACYBP to work on how calcium signals influence protein turnover.
CACYBP is found in both the nucleus and the cytoplasm, so it is a candidate for studies of compartment-specific protein degradation.
CACYBP may be involved in calcium-dependent ubiquitination and the subsequent proteasomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes, and it participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
CACYBP stands for calcyclin binding protein. It is also known as SIP and S100A6BP. The NCBI Gene summary reports two alternatively spliced transcript variants that encode different isoforms, so check which isoform is relevant to your work.
Yes. Mouse and rat both carry a Cacybp orthologue of the human CACYBP gene. This supports comparative work in rodent systems; check the datasheet of any product for its validated reactivity.
Beta-catenin, calcyclin and other ubiquitination and calcium-signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9HB71; product specifications from Assay Genie datasheets.