DLL3
DLL3 (delta like canonical Notch ligand 3, also known as SCDO1) is a membrane-bound member of the delta protein ligand family of Notch ligands. It inhibits primary neurogenesis and contributes to somite boundary formation during segmentation of the paraxial mesoderm. Browse Assay Genie's current range of DLL3 research reagents below, or read on for the biology behind the target.
DLL3 is a ligand in the Notch signalling system. Its annotated functions are developmental: it inhibits primary neurogenesis, may be required to divert neurons along a specific differentiation pathway, and plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Researchers studying neural differentiation and embryonic patterning therefore often work with the DLL3 protein and its expression.
The DLL3 gene encodes Delta-like protein 3, a member of the delta protein ligand family. Family members act as Notch ligands and are characterised by a DSL domain, EGF repeats and a transmembrane domain, consistent with the protein's localisation to the membrane. RefSeq reports two transcript variants that encode distinct isoforms. Mouse and rat both carry an ortholog named Dll3, which allows the biology to be examined in common model organisms.
In the HGNC classification, DLL3 belongs to the canonical Notch ligands gene group. The gene was previously named delta (Drosophila)-like 3 and delta-like 3 (Drosophila), and SCDO1 is a recorded alias, a reference to its disease association. Mutations in the gene cause autosomal recessive spondylocostal dysostosis 1, a link that connects DLL3 to the segmentation of the body axis. Related ligands such as DLL4 belong to the same signalling system, so DLL3 is often studied alongside them when comparing how different Notch ligands act.
DLL3 inhibits primary neurogenesis and may help direct neurons along a specific differentiation pathway, making it relevant to studies of neural development.
DLL3 contributes to somite boundary formation in the paraxial mesoderm, so it is studied in models of vertebrate body segmentation.
As a canonical Notch ligand with a DSL domain and EGF repeats, DLL3 is used to explore ligand-specific roles within the Notch pathway.
Mutations in DLL3 cause autosomal recessive spondylocostal dysostosis 1, linking the gene to inherited skeletal and segmentation disorders.
DLL3 is a Notch ligand that inhibits primary neurogenesis and may be required to divert neurons along a specific differentiation pathway. It also plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
DLL3 is formally named delta like canonical Notch ligand 3, and UniProt lists Delta-like protein 3. SCDO1 is an alias, and older names include delta (Drosophila)-like 3. RefSeq describes two transcript variants encoding distinct isoforms.
Mouse and rat both have an ortholog called Dll3. In humans, mutations in the DLL3 gene cause autosomal recessive spondylocostal dysostosis 1. Check the datasheet of any product for its validated reactivity.
Other canonical Notch ligands and Notch pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NYJ7; product specifications from Assay Genie datasheets.