SHANK1
SHANK1 (SH3 and multiple ankyrin repeat domains 1, also known as SSTRIP, SPANK-1 and synamon) is a scaffold protein of the SHANK family. It appears to act as an adapter in the postsynaptic density of excitatory synapses, linking glutamate receptors to the actin cytoskeleton. Browse Assay Genie's current range of SHANK1 research reagents below, or read on for the biology behind the target.
SHANK1 seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses. There it interconnects receptors of the postsynaptic membrane, including NMDA-type and metabotropic glutamate receptors, with the actin-based cytoskeleton. The connection to NMDA-type receptors runs through complexes with GKAP and PSD-95, and the connection to metabotropic glutamate receptors runs through complexes with Homer. Through these links, the SHANK1 protein plays a role in the structural and functional organization of the dendritic spine and the synaptic junction.
The SHANK1 gene encodes a member of the SHANK (SH3 domain and ankyrin repeat containing) family. Family members act as scaffold proteins that are required for the development and function of neuronal synapses. The protein is found in the cytoplasm and is concentrated at the postsynaptic density of synapses. HGNC classes it within the ankyrin repeat domain containing, sterile alpha motif domain containing, PDZ domain containing and SH3 domain containing gene groups, which reflects its modular, multi-domain architecture.
Aliases for the gene include SSTRIP, SPANK-1 and synamon. According to the NCBI Gene summary, deletions in this gene may be associated with autism spectrum disorder in males, which makes SHANK1 a point of interest in studies of synaptic organisation and neurodevelopmental conditions. Mouse and rat both carry a Shank1 ortholog, and SHANK3 is another member of the same family.
SHANK1 is a scaffold required for the development and function of neuronal synapses, so it is a natural focus for studies of synaptic organisation.
As an adapter in the postsynaptic density, SHANK1 links NMDA-type and metabotropic glutamate receptors with GKAP/PSD-95, Homer and the actin cytoskeleton.
SHANK1 contributes to the structural and functional organization of the dendritic spine and synaptic junction.
Deletions in the SHANK1 gene may be associated with autism spectrum disorder in males, linking the scaffold to neurodevelopmental research.
SHANK1 seems to be an adapter protein in the postsynaptic density of excitatory synapses. It connects NMDA-type and metabotropic glutamate receptors, via GKAP/PSD-95 and Homer complexes, to the actin-based cytoskeleton, and helps organise the dendritic spine and synaptic junction.
The official name is SH3 and multiple ankyrin repeat domains 1. Aliases include SSTRIP, SPANK-1 and synamon. The protein belongs to the SHANK family, whose name refers to the SH3 domain and ankyrin repeats found in its members.
NCBI Gene reports that deletions in SHANK1 may be associated with autism spectrum disorder in males. Orthologs named Shank1 exist in both mouse and rat. Check the datasheet of any product for its validated reactivity.
Another SHANK family scaffold protein involved in synapse development and function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y566; product specifications from Assay Genie datasheets.