SERPINI1
SERPINI1 (serpin family I member 1), also known as neuroserpin or PI12, is a secreted serine protease inhibitor of the serpin family. It inhibits plasminogen activators and plasmin, and is linked to synaptic plasticity and axonal growth in the nervous system. Browse Assay Genie's current range of SERPINI1 research reagents below, or read on for the biology behind the target.
SERPINI1 encodes neuroserpin, a serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. It preferentially reacts with and inhibits tissue-type plasminogen activator (tPA), and it may protect neurons from cell damage caused by tPA. The protein is primarily secreted by axons in the brain, and it is thought to contribute to the regulation of axonal growth and to the development of synaptic plasticity.
Neuroserpin belongs to the serpin superfamily of serine proteinase inhibitors. UniProt records it as secreted, within the lumen of secretory vesicles in the cytoplasm, and in the perikaryon. Its function annotation suggests a role in the formation or reorganisation of synaptic connections, and in synaptic plasticity in the adult nervous system. Researchers studying the SERPINI1 gene or neuroserpin protein often do so in the context of tPA regulation and neuronal biology.
Mutations in the SERPINI1 gene cause familial encephalopathy with neuroserpin inclusion bodies (FENIB). This dominantly inherited form of familial encephalopathy and epilepsy is characterised by the accumulation of mutant neuroserpin polymers. Several alternatively spliced variants have been identified, all encoding the same protein. The gene was previously named serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1, and carries the alias PI12. Orthologues are annotated in mouse and rat as Serpini1.
Neuroserpin may contribute to the formation or reorganisation of synaptic connections and to synaptic plasticity in the adult nervous system.
The protein is secreted primarily by axons in the brain and is thought to help regulate axonal growth.
Neuroserpin inhibits plasminogen activators and plasmin, preferentially tissue-type plasminogen activator, making it a model for serpin-protease interactions.
Mutations in SERPINI1 cause FENIB, in which mutant neuroserpin polymers accumulate, a focus for studies of encephalopathy and epilepsy.
SERPINI1 encodes neuroserpin, a serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. It preferentially inhibits tissue-type plasminogen activator, may protect neurons from tPA-mediated damage, and is thought to influence axonal growth and synaptic plasticity.
SERPINI1 is the HGNC symbol for serpin family I member 1. The protein is called neuroserpin, and PI12 is a recorded alias. The earlier gene name was serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1. Several splice variants all encode the same protein.
Mutations in SERPINI1 cause familial encephalopathy with neuroserpin inclusion bodies (FENIB), a dominantly inherited encephalopathy and epilepsy marked by mutant neuroserpin polymers. Mouse and rat both have a Serpini1 orthologue; check the datasheet of any product for its validated reactivity.
Other serpins, plasminogen activator pathway proteins and neuronal markers related to neuroserpin biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99574; product specifications from Assay Genie datasheets.