APOL4
APOL4 (apolipoprotein L4, also known as APOLIV) is a secreted member of the apolipoprotein L family. It is proposed to contribute to lipid exchange and transport and to reverse cholesterol transport. Browse Assay Genie's current range of APOL4 research reagents below, or read on for the biology behind the target.
APOL4 is an apolipoprotein that may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport, the movement of cholesterol from peripheral cells to the liver. The annotation is cautious in both cases: these roles are described as possible functions rather than fully established mechanisms, so APOL4 remains an interesting candidate for researchers working on lipid biology.
The APOL4 protein is classed as a secreted protein and belongs to the apolipoprotein L family. In HGNC the APOL4 gene sits within the apolipoproteins gene group, alongside other family members such as APOL1, APOL2 and APOL6. The gene encodes a single protein, and alternative splicing of the APOL4 gene gives rise to multiple transcript variants, which is worth bearing in mind when designing expression studies.
The official name is apolipoprotein L4, and APOLIV is a recognised alias. Because the available functional annotation centres on lipid handling, APOL4 is usually studied in the context of lipid transport and cholesterol metabolism, often in comparison with the other apolipoprotein L proteins. Researchers measuring APOL4 by an APOL4 antibody or APOL4 ELISA kit approach should check the reagent documentation, as the secreted form is the one relevant to extracellular lipid transport.
APOL4 may play a role in lipid exchange and transport throughout the body, making it a candidate for studies of lipid handling.
APOL4 may participate in reverse cholesterol transport from peripheral cells to the liver, relevant to cholesterol metabolism research.
As a member of the apolipoprotein L family, APOL4 supports comparative work across related apolipoproteins such as APOL1, APOL2 and APOL6.
Alternative splicing produces multiple APOL4 transcript variants, so the gene is relevant to studies of isoform-level expression and regulation.
APOL4 may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport, moving cholesterol from peripheral cells to the liver. These functions are described as putative in UniProt and NCBI Gene, and the protein is secreted.
APOL4 is the symbol for apolipoprotein L4, and APOLIV is a listed alias. NCBI Gene reports that alternative splicing of the APOL4 gene results in multiple transcript variants. Check the datasheet of any product for its validated reactivity and the variants it detects.
APOL4 belongs to the apolipoprotein L family and is listed in the HGNC apolipoproteins gene group. Related family members with their own pages include APOL1, APOL2 and APOL6. Orthologue information for mouse and rat is not given in the source data used here.
Other apolipoprotein L family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BPW4; product specifications from Assay Genie datasheets.