EFNB3
EFNB3 (ephrin B3, also known as LERK-8 and EPLG8) is a member of the ephrin family of ligands for EPH receptor tyrosine kinases. It is a membrane-bound protein linked to brain development and maintenance, and it also serves as a receptor for nipah and hendra viruses. Browse Assay Genie's current range of EFNB3 research reagents below, or read on for the biology behind the target.
EFNB3 is a member of the ephrin gene family. Ephrins are ligands for the EPH and EPH-related receptors, which make up the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and two fibronectin type III repeats. In addition to its role as an ephrin ligand, EFNB3 acts as a receptor for nipah virus and hendra virus.
Based on their structures and sequence relationships, ephrins are divided into the ephrin-A class, which is anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B class, which comprises transmembrane proteins. Ephrin-B3 belongs to the ephrin-B class. The EPH receptors are similarly divided into two groups based on the similarity of their extracellular domains and their affinities for binding ephrin-A or ephrin-B ligands. UniProt annotates the EFNB3 protein as a membrane protein.
The NCBI Gene summary describes EFNB3 as important in brain development and in its maintenance. Expression of EFNB3 is particularly high in several forebrain subregions compared with other brain subregions, which suggests a pivotal role in forebrain function. The ephrin ligands and receptors were named by the Eph Nomenclature Committee in 1997; the symbols LERK-8 and EPLG8 are alternative names for the EFNB3 gene.
EFNB3 is important in brain development and maintenance, making it a relevant ligand for studying EPH receptor signalling in the developing nervous system.
EFNB3 expression is particularly high in several forebrain subregions, suggesting a pivotal role in forebrain function.
EFNB3 acts as a receptor for nipah virus and hendra virus, so it is relevant to studies of viral entry.
As an ephrin-B class transmembrane ligand, EFNB3 helps define how ephrin-B ligands engage EPH receptors in developmental events.
EFNB3 is an ephrin-B class ligand for EPH receptor tyrosine kinases and is important in brain development and its maintenance. Its expression is particularly high in several forebrain subregions. It also acts as a receptor for nipah virus and hendra virus.
The HGNC name is ephrin B3, and UniProt lists the protein as Ephrin-B3. Aliases include LERK-8 and EPLG8. Ephrins and EPH receptors were named by the Eph Nomenclature Committee in 1997, and EFNB3 belongs to the ephrin-B class.
Ephrin-A ligands are anchored to the membrane by a glycosylphosphatidylinositol linkage, whereas ephrin-B ligands such as EFNB3 are transmembrane proteins. The two classes bind different EPH receptor groups. A mouse ortholog, Efnb3, exists; check the datasheet of any product for its validated reactivity.
Other ephrin-B ligands and related EPH receptor pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15768; product specifications from Assay Genie datasheets.