GPC6
GPC6 (glypican 6) is a cell surface proteoglycan that bears heparan sulfate and belongs to the glypican family. It is a putative coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases, and is linked to cancer cell migration through WNT5A signalling. Browse Assay Genie's current range of GPC6 research reagents below, or read on for the biology behind the target.
GPC6 is a cell surface proteoglycan that carries heparan sulfate chains. It is considered a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases, placing it at the interface between the cell and its surrounding environment. In cancer cells, GPC6 enhances migration and invasion through WNT5A signalling.
The glypicans make up a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and have been implicated in the control of cell growth and cell division. GPC6 is annotated as belonging to this family, and the HGNC places the GPC6 gene in the Glypicans gene group. UniProt records the protein at the cell membrane and in the extracellular space, consistent with a membrane-anchored proteoglycan that can also be found in a secreted form. The mouse ortholog is Gpc6.
Mutations in the GPC6 gene are associated with omodysplasia 1, which connects the protein to skeletal development in human disease. Researchers studying glypican biology often compare GPC6 with other family members such as GPC1, GPC2, GPC4 and GPC5, to understand which functions are shared across glypicans and which are specific to individual proteins.
GPC6 is a heparan sulfate proteoglycan and a member of the glypican family, making it a useful subject for studying cell surface glycoconjugates.
GPC6 enhances migration and invasion of cancer cells through WNT5A signalling, which makes it relevant to studies of tumour cell behaviour.
As a putative coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases, GPC6 is of interest in cell surface signalling research.
Mutations in the GPC6 gene are associated with omodysplasia 1, supporting its use in research on inherited skeletal disorders.
GPC6 is a cell surface proteoglycan that bears heparan sulfate. It is a putative coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. In cancer cells it enhances migration and invasion through WNT5A signalling. Glypicans in general have been implicated in the control of cell growth and cell division.
The approved HGNC name is glypican 6, and UniProt lists the protein as Glypican-6. No alternative aliases or previous symbols are recorded. GPC6 belongs to the glypican family, a group of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans that includes GPC1, GPC2, GPC4 and GPC5.
Mutations in the GPC6 gene are associated with omodysplasia 1. A mouse ortholog, Gpc6, is recorded, so rodent models can be used for comparative work. Check the datasheet of any product for its validated reactivity.
Other glypican family heparan sulfate proteoglycans with research products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y625; product specifications from Assay Genie datasheets.