BCL2L2
BCL2L2, also known as Bcl-w, is a member of the Bcl-2 family that promotes cell survival and blocks apoptosis. The gene is also catalogued under the aliases KIAA0271 and PPP1R51. Browse Assay Genie's current range of BCL2L2 research reagents below, or read on for the biology behind the target.
BCL2L2 (BCL2 like 2) encodes Bcl-2-like protein 2, a member of the Bcl-2 family. Proteins of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. In postmitotic Sertoli cells it mediates survival by suppressing the death-promoting activity of BAX. Expression of the gene has been shown to reduce apoptosis under cytotoxic conditions. The protein localises to the mitochondrial membrane.
The BCL2L2 gene is a member of two HGNC groups: the BCL2 family and the protein phosphatase 1 regulatory subunits, which explains the alias PPP1R51. Other names include Bcl-w and KIAA0271. Alternative splicing gives rise to multiple transcript variants. Read-through transcription also occurs between this gene and the neighbouring downstream gene PABPN1 (poly(A) binding protein, nuclear 1).
Work on the mouse ortholog, Bcl2l2, points to a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene showed an essential role in adult spermatogenesis. This makes the BCL2L2 protein a useful subject for studies of apoptosis control, neuronal survival and male germ-cell biology, alongside related Bcl-2 family members.
BCL2L2 is an anti-apoptotic Bcl-2 family member that reduces cell death under cytotoxic conditions and blocks dexamethasone-induced apoptosis.
It supports postmitotic Sertoli cell survival by suppressing BAX, and mouse knockout studies show it is essential for adult spermatogenesis.
Studies of the mouse ortholog indicate a role in the survival of NGF- and BDNF-dependent neurons.
Bcl-2 family proteins form hetero- and homodimers, so BCL2L2 is relevant to studies of pro- and anti-apoptotic balance at the mitochondrion.
BCL2L2 is an anti-apoptotic Bcl-2 family protein that promotes cell survival. It blocks dexamethasone-induced apoptosis and, in postmitotic Sertoli cells, suppresses the death-promoting activity of BAX. It is found at the mitochondrial membrane.
BCL2L2 is also called Bcl-w, KIAA0271 and PPP1R51, and its protein name is Bcl-2-like protein 2. Alternative splicing produces multiple transcript variants, and read-through transcription links the gene with the neighbouring PABPN1 gene.
A mouse ortholog, Bcl2l2, exists. Mouse studies indicate a role in the survival of NGF- and BDNF-dependent neurons, and mutation and knockout work shows it is essential for adult spermatogenesis. Check the datasheet of any product for its validated reactivity.
Other Bcl-2 family members and BCL-named proteins involved in apoptosis and cell survival, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92843; product specifications from Assay Genie datasheets.