ANGPTL7
ANGPTL7 (angiopoietin like 7) is a secreted member of the angiopoietin-like family that contributes to extracellular matrix formation and organisation. It is also known as CDT6 and AngX, and has a defined role in maintaining corneal avascularity. Browse Assay Genie's current range of ANGPTL7 research reagents below, or read on for the biology behind the target.
ANGPTL7 has a role in the formation and organisation of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humour and for the maintenance of intraocular pressure. It is also a negative regulator of angiogenesis in the cornea, where it plays a major role in maintaining corneal avascularity and transparency.
The ANGPTL7 protein is located in the extracellular region and is annotated as secreted. NCBI Gene records that it enables identical protein binding activity and is involved in negative regulation of vasculature development during avascular cornea development in the camera-type eye, as well as in regulation of extracellular matrix organisation. The ANGPTL7 gene lies in the HGNC groups for receptor ligands, fibrinogen C domain containing proteins and the angiopoietin like family. The mouse ortholog is Angptl7.
The approved name is angiopoietin like 7, with the previous name angiopoietin-like 7 and the aliases CDT6 and AngX. UniProt lists the protein as angiopoietin-related protein 7. Researchers studying matrix remodelling, ocular tissue biology and the control of vessel growth in avascular tissues will find ANGPTL7 a relevant target alongside other angiopoietin-like proteins.
ANGPTL7 is a negative regulator of angiogenesis in the cornea and plays a major role in maintaining corneal avascularity and transparency.
It mediates dexamethasone-induced matrix deposition in the trabecular meshwork, which governs aqueous humour outflow and intraocular pressure.
ANGPTL7 has a role in the formation and organisation of the extracellular matrix and is involved in its regulation.
Its involvement in negative regulation of vasculature development makes it a useful target for studying inhibitory control of vessel growth.
ANGPTL7 has a role in forming and organising the extracellular matrix. In the eye it mediates dexamethasone-induced matrix deposition in the trabecular meshwork and negatively regulates corneal angiogenesis, helping maintain corneal avascularity and transparency.
ANGPTL7 stands for angiopoietin like 7, previously written angiopoietin-like 7. Aliases include CDT6 and AngX, and UniProt names the protein angiopoietin-related protein 7. It belongs to the angiopoietin like family and the fibrinogen C domain containing group.
A mouse ortholog, Angptl7, is recorded for the human gene. A rat ortholog is not specified in the data used here. Check the datasheet of any product for its validated reactivity.
Other angiopoietin-like family members that share the fibrinogen C domain and act as secreted receptor ligands.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O43827; product specifications from Assay Genie datasheets.