SYNPO2
SYNPO2 (synaptopodin 2, also known as myopodin) is an actin-associated member of the synaptopodin family. It is involved in regulating cell migration, and it can promote focal adhesion formation, actin bundling and lamellipodia at the leading cell edge. Browse Assay Genie's current range of SYNPO2 research reagents below, or read on for the biology behind the target.
SYNPO2 is involved in the regulation of cell migration, in part through the Rho-ROCK cascade. It can promote the formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia. It can also induce thick, irregular actin bundles in the cell body, and this induced actin network is associated with enhanced cell migration in vitro. The NCBI Gene summary describes it as involved in positive regulation of actin filament bundle assembly and positive regulation of cell migration, and it also lists a role in regulating Rho-dependent protein serine/threonine kinase activity.
At the molecular level, SYNPO2 enables alpha-actinin binding and filamin binding. These activities fit its localisation to the actin cytoskeleton. UniProt records it in the nucleus, in the cytoplasm and cytoskeleton, at the sarcomere Z line and at focal adhesions. The NCBI Gene summary also places it at the Z disc and on stress fibres. Researchers studying the SYNPO2 gene or SYNPO2 protein therefore often work on actin organisation and cell motility.
The protein belongs to the synaptopodin family, and HGNC classifies the gene in the PDZ domain containing group. Its approved name is synaptopodin 2, and it is also known as myopodin. Mouse and rat both have a Synpo2 ortholog, so the protein can be studied in common rodent models. SYNPO, the related synaptopodin gene, is a natural companion target for comparative work within the family.
SYNPO2 regulates cell migration in part through the Rho-ROCK cascade, and its induced actin network is associated with enhanced migration in vitro.
SYNPO2 promotes actin filament bundle assembly and can induce thick, irregular actin bundles in the cell body.
SYNPO2 can promote nascent focal adhesions and lamellipodia at the leading edge, and it is located at focal adhesions.
SYNPO2 is located at the sarcomere Z line and binds alpha-actinin and filamin, two actin-crosslinking partners.
SYNPO2 is involved in regulating cell migration, in part through the Rho-ROCK cascade. It can promote nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia, and it can induce thick actin bundles in the cell body.
SYNPO2 is the approved symbol for synaptopodin 2, and UniProt names the protein Synaptopodin-2. It is also known as myopodin. The protein belongs to the synaptopodin family, and HGNC places the gene in the PDZ domain containing group.
Yes. Both mouse and rat have an ortholog named Synpo2, so the target can be studied in common rodent models. Cross-species use depends on the reagent, so check the datasheet of any product for its validated reactivity.
Synaptopodin family members and related actin-cytoskeleton targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UMS6; product specifications from Assay Genie datasheets.