FLOT1
FLOT1 (flotillin 1) is a membrane-associated protein of the flotillin subfamily that is thought to act as a scaffold within caveolar membranes. It is linked to caveola formation, vesicle trafficking and cell morphology. Browse Assay Genie's current range of FLOT1 research reagents below, or read on for the biology behind the target.
FLOT1 is described in UniProt as a protein that may act as a scaffolding protein within caveolar membranes, functionally participating in the formation of caveolae or caveolae-like vesicles. Caveolae are small domains on the inner surface of the cell membrane, and the NCBI Gene summary reports that the protein localises to them and plays a role in vesicle trafficking and cell morphology.
Flotillin-1 belongs to the band 7/mec-2 family and the flotillin subfamily. UniProt records its subcellular locations as the cell membrane, endosome, caveola, melanosome and membrane raft. The FLOT1 gene lies at 6p21.33, and alternative splicing of the gene is reported to give rise to multiple transcript variants. Mouse and rat both carry an ortholog named Flot1.
In the HGNC classification, FLOT1 sits in the flotillins gene group, which also includes FLOT2. Researchers studying membrane microdomains, endocytic and vesicular pathways, or the organisation of caveolae often use the FLOT1 gene and Flotillin-1 protein as markers and as subjects of investigation. The UniProt function annotation is cautious ("may act as"), so the precise molecular mechanisms remain an active area of study.
FLOT1 may act as a scaffold within caveolar membranes and takes part in the formation of caveolae or caveolae-like vesicles.
Flotillin-1 is annotated to the membrane raft, making it a relevant protein for work on membrane microdomain organisation.
The NCBI Gene summary assigns FLOT1 a role in vesicle trafficking, and UniProt places it in endosomes as well as at the cell membrane.
FLOT1 is reported to play a role in cell morphology, linking membrane domain organisation to cell shape.
UniProt states that FLOT1 may act as a scaffolding protein within caveolar membranes, participating in the formation of caveolae or caveolae-like vesicles. The NCBI Gene summary adds roles in vesicle trafficking and cell morphology.
The HGNC approved name is flotillin 1 and UniProt lists the protein as Flotillin-1. No alternative symbols are recorded. NCBI Gene reports that alternative splicing results in multiple transcript variants of the FLOT1 gene.
Mouse and rat both have a Flot1 ortholog. FLOT1 is a member of the HGNC flotillins group alongside FLOT2, and belongs to the band 7/mec-2 family. Check the datasheet of any product for its validated reactivity.
Other flotillin family members and related membrane microdomain targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75955; product specifications from Assay Genie datasheets.