ANKRD52
ANKRD52 (ankyrin repeat domain 52) is a putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in recognising phosphoprotein substrates. It is also known as PP6-ARS-C and FLJ34236. Browse Assay Genie's current range of ANKRD52 research reagents below, or read on for the biology behind the target.
ANKRD52 is annotated as a putative regulatory subunit of protein phosphatase 6 (PP6). Regulatory subunits of this kind are thought to help a phosphatase catalytic subunit select its targets, and UniProt records that ANKRD52 may be involved in the recognition of phosphoprotein substrates. The wording is cautious: the function is described as putative and the evidence is limited to that annotation.
The protein is named serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C in UniProt, which is abbreviated to PP6-ARS-C. The name reflects its ankyrin repeat domains, which are the basis of its HGNC classification in the group of ankyrin repeat domain containing proteins. HGNC also places it in the group of protein phosphatase 6 regulatory subunits. The ANKRD52 gene is found on chromosome 12, and the mouse ortholog is Ankrd52.
The symbol ANKRD52 stands for ankyrin repeat domain 52, and FLJ34236 is a further alias for the gene. Researchers studying PP6 complexes, phosphoprotein substrate selection or ankyrin repeat proteins may therefore come across ANKRD52 under any of these names. Subcellular location and tissue expression are not annotated in the sources used for this page, so they are not described here.
ANKRD52 is a putative regulatory subunit of protein phosphatase 6, making it a candidate for studies of how PP6 assemblies are organised.
ANKRD52 may be involved in recognising phosphoprotein substrates, which makes it relevant to work on how phosphatases select their targets.
As a member of the ankyrin repeat domain containing group, ANKRD52 is useful for comparing ankyrin repeat proteins and their roles.
The mouse ortholog Ankrd52 allows the gene and its putative PP6 regulatory role to be investigated in a model organism.
UniProt describes ANKRD52 as a putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. The annotation is tentative, and no further functional detail is given in the sources used here.
The HGNC name is ankyrin repeat domain 52. Aliases are FLJ34236 and PP6-ARS-C, and the UniProt name is serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C. Searching under any of these should help you find the same gene and protein.
Yes, the mouse ortholog is Ankrd52. A rat ortholog is not given in the data used for this page. Cross-species reactivity varies, so check the datasheet of any product for its validated reactivity.
Other ankyrin repeat domain containing proteins with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8NB46; product specifications from Assay Genie datasheets.