RAB27B
RAB27B (Ras-related protein Rab-27B) is a member of the Rab family of small GTPases, which regulate intracellular membrane trafficking. It controls homeostasis of the late endocytic pathway, including endosomal positioning, maturation and secretion. Browse Assay Genie's current range of RAB27B research reagents below, or read on for the biology behind the target.
RAB27B belongs to the small GTPase superfamily and the Rab family. Rab proteins are key regulators of intracellular membrane trafficking, acting from the formation of transport vesicles through to their fusion with target membranes. Like other Rabs, RAB27B cycles between an inactive GDP-bound form and an active GTP-bound form. The active form recruits distinct sets of downstream effectors to membranes, and these effectors are directly responsible for vesicle formation, movement, tethering and fusion.
Within this framework, RAB27B regulates homeostasis of the late endocytic pathway, including endosomal positioning, maturation and secretion. UniProt reports that it is associated with membranes and the late endosome, while NCBI Gene annotation places it in the Golgi stack and cytoplasmic vesicles. Reported molecular functions include guanyl ribonucleotide binding, myosin V binding and protein domain specific binding, and it is involved in the multivesicular body sorting pathway and in positive regulation of exocytosis.
RAB27B also has cargo-specific roles. It plays a part in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1, and it may be involved in targeting uroplakins to urothelial apical membranes. The RAB27B gene is classed by HGNC in the group of RAB, member RAS oncogene GTPases, and the protein carries the GTPase enzyme classification EC 3.6.5.2. Mouse and rat both have a Rab27b ortholog.
RAB27B is a Rab GTPase that helps regulate vesicle formation, movement, tethering and fusion, making it a useful model for studying intracellular transport.
RAB27B regulates endosomal positioning, maturation and secretion, and positively regulates exocytosis through the multivesicular body sorting pathway.
RAB27B facilitates association of NTRK2/TRKB with KLC1 during axonal anterograde transport, linking Rab function to neurotrophin receptor trafficking.
RAB27B may be involved in targeting uroplakins to urothelial apical membranes, relevant to studies of urothelial membrane organisation.
RAB27B is a small GTPase that regulates the late endocytic pathway, including endosomal positioning, maturation and secretion. Like other Rabs, it switches between an inactive GDP-bound state and an active GTP-bound state that recruits effectors for vesicle formation, movement, tethering and fusion.
Both are Rab family small GTPases, and RAB27A has its own page in this set of targets. RAB27B is encoded by a separate gene on chromosome 18 and is described here in terms of late endosome regulation, NTRK2/TRKB transport and uroplakin targeting.
Yes. Mouse and rat each have a Rab27b ortholog of the human gene. Rab proteins as a group are conserved regulators of membrane trafficking; check the datasheet of any product for its validated reactivity.
Other Rab family GTPases and regulators of endosomal trafficking and exocytosis with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00194; product specifications from Assay Genie datasheets.