CDCA5
CDCA5 (cell division cycle associated 5), also known by its UniProt protein name sororin, is a regulator of sister chromatid cohesion in mitosis. It stabilises the association of the cohesin complex with chromatin and is required for efficient DNA double-strand break repair. Browse Assay Genie's current range of CDCA5 research reagents below, or read on for the biology behind the target.
CDCA5 regulates sister chromatid cohesion during mitosis. It acts by stabilising the association of the cohesin complex with chromatin, and it may antagonise the action of WAPL, which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells, and it also plays an important role in DNA repair. CDCA5 is required for efficient DNA double-strand break repair.
The CDCA5 gene encodes a protein that belongs to the sororin family. UniProt records its subcellular locations as the nucleus, chromosome and cytoplasm, while the NCBI Gene summary describes it as located in the nucleoplasm and predicted to enable chromatin binding activity. The same summary lists its involvement in double-strand break repair and mitotic sister chromatid cohesion. A mouse ortholog, Cdca5, is recognised, which allows the cohesion and repair functions of the protein to be studied in murine systems.
The approved HGNC name, cell division cycle associated 5, reflects its link to cell cycle progression, while the UniProt name sororin describes its role in cohesion. Researchers studying CDCA5 typically work on chromosome segregation, cohesin dynamics on chromatin and the maintenance of genome integrity through DNA repair.
CDCA5 stabilises cohesin association with chromatin, making it a key subject for studying how sister chromatids stay paired until mitosis.
Cohesion ensures accurate chromosome partitioning in meiotic and mitotic cells, so CDCA5 is relevant to studies of faithful cell division.
CDCA5 is required for efficient double-strand break repair, linking cohesion machinery to the maintenance of genome integrity.
CDCA5 may antagonise WAPL, which stimulates cohesin dissociation from chromatin, offering a route into cohesin turnover research.
CDCA5 regulates sister chromatid cohesion in mitosis by stabilising cohesin complex association with chromatin. It may antagonise WAPL, which stimulates cohesin dissociation. It is also required for efficient DNA double-strand break repair, supporting accurate chromosome partitioning and genome integrity.
Yes. Sororin is the UniProt protein name for the product of the CDCA5 gene, whose HGNC name is cell division cycle associated 5. The protein belongs to the sororin family, which takes its name from this member.
A mouse ortholog, Cdca5, is recognised for the human gene. Cohesion and DNA repair are processes shared across mitotic and meiotic cells, so murine models are relevant to CDCA5 research. Check the datasheet of any product for its validated reactivity.
Other cell division cycle associated proteins involved in mitotic regulation, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96FF9; product specifications from Assay Genie datasheets.