DLG3
DLG3 (discs large MAGUK scaffold protein 3, also known as SAP102, NE-Dlg and MRX90) is a member of the membrane-associated guanylate kinase family. It is linked to NMDA receptor clustering at excitatory synapses and to learning. Browse Assay Genie's current range of DLG3 research reagents below, or read on for the biology behind the target.
DLG3 is a scaffold protein of the membrane-associated guanylate kinase (MAGUK) family. According to UniProt, it is required for learning, most likely through its role in synaptic plasticity following NMDA receptor signalling. The NCBI Gene summary adds that the encoded protein may play a role in clustering NMDA receptors at excitatory synapses, which places it among the proteins that organise the postsynaptic machinery.
The summary also notes that DLG3 may negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli (APC) tumour suppressor protein. This suggests a function outside the synapse as well as within it. Alternatively spliced transcript variants have been described for the DLG3 gene.
HGNC places DLG3 in several groups: protein phosphatase 1 regulatory subunits, membrane associated guanylate kinases, PDZ domain containing and SH3 domain containing proteins. The protein is also known as SAP102, SAP-102, NE-Dlg, NEDLG, KIAA1232 and PPP1R82, and the gene was previously named for its relationship to the Drosophila discs large homolog (neuroendocrine-dlg). Mutations in the gene have been associated with X-linked cognitive disability, reflected in the alias MRX90. Mouse and rat both carry an orthologous gene, Dlg3, which allows the protein to be studied in common model systems.
DLG3 is required for learning, most likely through its role in synaptic plasticity following NMDA receptor signalling.
The protein may contribute to clustering of NMDA receptors at excitatory synapses, making it relevant to postsynaptic organisation.
Mutations in the DLG3 gene have been associated with X-linked cognitive disability, linking it to neurodevelopmental research.
DLG3 may negatively regulate cell proliferation through interaction with the C-terminal region of the APC tumour suppressor protein.
DLG3 is a MAGUK family scaffold protein. UniProt reports that it is required for learning, most likely through synaptic plasticity following NMDA receptor signalling. It may also cluster NMDA receptors at excitatory synapses and may negatively regulate cell proliferation through interaction with APC.
DLG3 is also called SAP102, SAP-102, NE-Dlg, NEDLG, KIAA1232, MRX90 and PPP1R82. Its UniProt name is Disks large homolog 3. Older HGNC names refer to the Drosophila discs large homolog and neuroendocrine-dlg. Alternatively spliced transcript variants have been described.
Mutations in the DLG3 gene have been associated with X-linked cognitive disability, hence the alias MRX90. The gene has orthologues named Dlg3 in both mouse and rat. Check the datasheet of any product for its validated reactivity.
Other discs large family members and related scaffold proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92796; product specifications from Assay Genie datasheets.