HCRTR1
HCRTR1 (hypocretin receptor 1, also known as OX1R, OXR1 and ORXR1) is a G protein-coupled receptor for the neuropeptide orexin-A. It signals through a G(q)-coupled pathway and plays a significant role in the regulation of food intake. Browse Assay Genie's current range of HCRTR1 research reagents below, or read on for the biology behind the target.
HCRTR1 is a G protein-coupled receptor that binds the neuropeptide orexin-A with high affinity and orexin-B with lower affinity. Both peptides are derived from a common precursor, prepro-orexin. Receptor activity is mediated through a G(q)-protein-coupled pathway, which activates the phosphatidylinositol-calcium second messenger system in response to orexin-A binding. In addition to G(q)-mediated signalling, orexin-A stimulation promotes beta-arrestin recruitment, which leads to receptor internalisation.
The HCRTR1 protein is a cell membrane receptor and belongs to the G protein-coupled receptor 1 family. NCBI Gene describes it as selectively binding the hypothalamic neuropeptide orexin A, and UniProt annotates a significant role in the regulation of food intake. The HCRTR1 gene is therefore studied in the context of feeding behaviour and orexin signalling.
HCRTR1 is the approved HGNC symbol for hypocretin receptor 1, previously named hypocretin (orexin) receptor 1, and the receptor is also called OX1R, OXR1 and ORXR1. It sits in the HGNC gene group of hypocretin receptors. A related gene, HCRTR2, encodes a G protein-coupled receptor that binds both orexin A and orexin B. Mouse and rat orthologs are both designated Hcrtr1.
HCRTR1 is involved in the regulation of feeding behaviour, making it a relevant target for studies of food intake.
The receptor binds orexin-A with high affinity and orexin-B with lower affinity, both derived from prepro-orexin.
Orexin-A binding activates G(q) signalling and the phosphatidylinositol-calcium second messenger system.
Orexin-A stimulation promotes beta-arrestin recruitment, leading to HCRTR1 internalisation from the cell membrane.
HCRTR1 is a G protein-coupled receptor for orexin-A, and binds orexin-B with lower affinity. It signals via G(q) to activate the phosphatidylinositol-calcium second messenger system, and also recruits beta-arrestin, leading to internalisation. It plays a significant role in the regulation of food intake.
HCRTR1 stands for hypocretin receptor 1, previously named hypocretin (orexin) receptor 1. Aliases include OX1R, OXR1 and ORXR1, and UniProt lists the protein as orexin/hypocretin receptor type 1. The names reflect the two terms, orexin and hypocretin, used for its peptide ligands.
Both are G protein-coupled receptors for orexin peptides. NCBI Gene notes that HCRTR1 selectively binds orexin A, whereas the related HCRTR2 binds both orexin A and orexin B. Mouse and rat Hcrtr1 orthologs exist; check the datasheet of any product for its validated reactivity.
Other orexin receptors, orexin precursor and G protein-coupled receptor signalling partners with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O43613; product specifications from Assay Genie datasheets.