PTP4A3
PTP4A3 (protein tyrosine phosphatase 4A3, also known as PRL-3, PRL-R and PRL3) is a protein tyrosine phosphatase that promotes cell cycle progression, proliferation and motility. Overexpression of the PTP4A3 gene has been implicated in tumour metastasis. Browse Assay Genie's current range of PTP4A3 research reagents below, or read on for the biology behind the target.
PTP4A3 is a protein tyrosine phosphatase, an enzyme that removes phosphate groups from tyrosine residues on substrate proteins. Protein tyrosine phosphatases are cell signalling molecules with regulatory roles in a variety of cellular processes. PTP4A3 stimulates progression from G1 into S phase during mitosis, and it enhances cell proliferation, cell motility and invasive activity. It has also been reported to promote cancer metastasis.
UniProt places PTP4A3 at the cell membrane and in early endosomes. This fits NCBI Gene summary data from mouse studies, which show that proteins of this class are prenylated in vivo, suggesting an association with the plasma membrane. The protein belongs to the protein-tyrosine phosphatase family, and HGNC classes the gene in the protein tyrosine phosphatase 4A family. The mouse ortholog is Ptp4a3. Alternative splicing of the PTP4A3 gene results in multiple transcript variants.
Beyond cancer biology, PTP4A3 may be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilisation in response to angiotensin II. The protein is also known as PRL-3, PRL-R and PRL3, and the previous HGNC name was protein tyrosine phosphatase type IVA, member 3. These names appear across the literature, so searching on all of them helps when reviewing PTP4A3 research.
Overexpression of PTP4A3 has been implicated in tumour metastasis, and the protein promotes cell motility and invasive activity.
PTP4A3 stimulates progression from G1 into S phase and enhances cell proliferation, making it relevant to studies of mitotic control.
As a protein tyrosine phosphatase, PTP4A3 contributes to the regulation of cell signalling processes through tyrosine dephosphorylation.
PTP4A3 may contribute to cardiac hypertrophy by inhibiting intracellular calcium mobilisation in response to angiotensin II.
PTP4A3 is a protein tyrosine phosphatase that stimulates progression from G1 into S phase during mitosis. It enhances cell proliferation, motility and invasive activity, and promotes cancer metastasis. It may also affect cardiac hypertrophy by inhibiting calcium mobilisation in response to angiotensin II.
PTP4A3 is also called PRL-3, PRL-R and PRL3. The full name is protein tyrosine phosphatase 4A3, and UniProt lists it as protein tyrosine phosphatase type IVA 3. The earlier HGNC name was protein tyrosine phosphatase type IVA, member 3. Alternative splicing gives multiple transcript variants.
Overexpression of the PTP4A3 gene has been implicated in tumour metastasis. A mouse ortholog, Ptp4a3, exists, and mouse studies indicate that this class of phosphatase is prenylated in vivo, suggesting association with the plasma membrane. Check the datasheet of any product for its validated reactivity.
Other protein tyrosine phosphatases, both non-receptor and receptor-type, that are relevant to signalling and cancer research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75365; product specifications from Assay Genie datasheets.