DLG1
DLG1 (discs large MAGUK scaffold protein 1, also known as SAP97, SAP-97, hdlg and DLGH1) is a multidomain scaffolding protein of the MAGUK family. It is required for normal development and organises channels, receptors and signalling molecules at the plasma membrane of polarised cells. Browse Assay Genie's current range of DLG1 research reagents below, or read on for the biology behind the target.
DLG1 is an essential multidomain scaffolding protein. It recruits channels, receptors and signalling molecules to discrete plasma membrane domains in polarised cells. In epithelia it promotes barrier function by maintaining cell-cell adhesion, and it may also contribute to adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.
The protein has specific roles in excitable cells. In cardiac myocytes, DLG1 regulates excitability by modulating the functional expression of Kv4 channels, and it acts as a functional regulator of the Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane. UniProt records DLG1 at the basolateral and apical cell membrane, the sarcolemma, the endoplasmic reticulum membrane, the postsynaptic density, cell junctions and the cytoplasm.
The DLG1 gene belongs to the HGNC groups for membrane associated guanylate kinases, PDZ domain containing proteins, SH3 domain containing proteins and the Scribble complex. Its earlier names include discs, large homolog 1 (Drosophila) and discs large homolog 1, scribble cell polarity complex component. NCBI Gene notes a role in septate junction formation and reports many transcript variants arising from alternative splicing and alternate promoters, including some that may be specific to brain and other tissues. An upstream open reading frame may regulate translation of some variants. Mouse and rat both have a Dlg1 ortholog.
DLG1 supports epithelial barrier function by maintaining cell-cell adhesion and may contribute to adherens junction assembly, making it relevant to polarity studies.
DLG1 is found at the postsynaptic density, may contribute to synaptogenesis and recruits ADAM10 to the plasma membrane during hippocampal long-term depression.
DLG1 modulates the functional expression of Kv4 channels and regulates Kv1.5, linking this scaffold to the excitability of cardiac myocytes.
DLG1 may take part in lymphocyte activation, signal transduction and cell proliferation, so it is studied as a scaffold for signalling complexes.
DLG1 is a scaffolding protein that recruits channels, receptors and signalling molecules to specific plasma membrane domains in polarised cells. It helps maintain epithelial barrier function through cell-cell adhesion and regulates Kv4 and Kv1.5 potassium channels in cardiac cells.
DLG1 is also called SAP97, SAP-97, hdlg and DLGH1. Earlier names include discs, large homolog 1 (Drosophila) and discs large homolog 1, scribble cell polarity complex component. UniProt lists the protein as Disks large homolog 1. NCBI Gene describes many splice variants of the gene.
DLG1 belongs to the MAGUK family and is named after the Drosophila discs large gene. Mouse and rat each have a Dlg1 ortholog. Check the datasheet of any product for its validated reactivity.
Other discs large family members and associated proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q12959; product specifications from Assay Genie datasheets.