FAM3D
FAM3D is a secreted member of the FAM3 family, predicted to have cytokine activity and linked to negative regulation of insulin secretion. It is also known as EF7 and OIT1, and was previously named family with sequence similarity 3 member D. Browse Assay Genie's current range of FAM3D research reagents below, or read on for the biology behind the target.
FAM3D (FAM3 metabolism regulating signalling molecule D) is a member of the FAM3 family. According to the NCBI Gene summary, it is predicted to enable cytokine activity and is involved in the negative regulation of insulin secretion. These annotations place the protein in the group of secreted signalling molecules that act on metabolic processes, although the summary describes the cytokine function as a prediction rather than an established property.
UniProt lists the FAM3D protein as secreted, and the gene summary likewise predicts that it is located in the extracellular region. The human FAM3D gene is the source of the protein, and the mouse ortholog is named Fam3d. Other FAM3 family members with related names include FAM3A, FAM3B and FAM3C, which are useful comparators when studying how this small family contributes to metabolic signalling.
The target has been catalogued under several names. The HGNC-approved name is FAM3 metabolism regulating signalling molecule D, the earlier name was family with sequence similarity 3 member D, and the aliases EF7 and OIT1 appear in the literature and databases. Researchers searching for the protein, whether by symbol or alias, should be aware of these alternative designations when comparing studies.
FAM3D is involved in the negative regulation of insulin secretion, making it relevant to studies of how secreted factors modulate insulin release.
The protein is predicted to enable cytokine activity, so it is of interest in work on secreted signalling molecules and their functions.
As a FAM3 metabolism regulating signalling molecule, FAM3D is a candidate for investigating extracellular factors that influence metabolic regulation.
FAM3D belongs to the FAM3 family, so it supports comparative studies alongside FAM3A, FAM3B and FAM3C.
According to the NCBI Gene summary, FAM3D is predicted to enable cytokine activity and is involved in the negative regulation of insulin secretion. It is a secreted protein, predicted to be located in the extracellular region. Its cytokine function is a prediction rather than a fully characterised activity.
The HGNC full name is FAM3 metabolism regulating signalling molecule D, and UniProt lists it as Protein FAM3D. Aliases include EF7 and OIT1, and the previous name was family with sequence similarity 3 member D. All refer to the same human gene.
A mouse ortholog, Fam3d, is recorded for the human gene. FAM3D belongs to the FAM3 family, which also includes FAM3A, FAM3B and FAM3C. For species reactivity, check the datasheet of any product for its validated reactivity.
Other FAM3 family members and further FAM-named proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96BQ1; product specifications from Assay Genie datasheets.