TTPAL
TTPAL (alpha tocopherol transfer protein like) is a human protein of the CRAL-TRIO lipid binding domain family. UniProt annotates it as a protein that may bind a hydrophobic ligand. It was previously known as C20orf121 and dJ179M20.3. Browse Assay Genie's current range of TTPAL research reagents below, or read on for the biology behind the target.
TTPAL is annotated in UniProt as a protein that may act by binding a hydrophobic ligand. The annotation is cautious, and the precise ligand and the biochemical role of the protein have not been defined in the sources used for this page. The NCBI Gene summary, provided by the Alliance of Genome Resources, adds that TTPAL is predicted to enable phosphatidylinositol bisphosphate binding activity and is located in the membrane. Together, these points suggest a protein that interacts with lipids at membranes, although the predicted binding activity is an inference and not a fully characterised function.
The human TTPAL gene is classed by HGNC within the CRAL-TRIO lipid binding domain containing group, a set of proteins defined by a shared lipid-binding domain. The gene's name reflects this relationship: the official full name, alpha tocopherol transfer protein like, indicates similarity to the alpha-tocopherol transfer protein. UniProt lists the protein as Alpha-tocopherol transfer protein-like. No enzymatic activity or EC number is assigned to it.
The gene was formerly designated chromosome 20 open reading frame 121 (C20orf121), and it also carries the clone-based identifier dJ179M20.3. Its earlier descriptive name was tocopherol (alpha) transfer protein-like. Researchers searching the literature or older databases may therefore meet any of these labels for the same gene. A mouse ortholog, Ttpal, is recorded, which allows comparative work in a mouse system. Because experimental annotation of this protein is limited, TTPAL is of interest mainly to researchers studying the CRAL-TRIO family and lipid-binding proteins that are poorly characterised.
TTPAL belongs to the CRAL-TRIO lipid binding domain group, making it a candidate for comparative studies of lipid-binding domain proteins.
UniProt describes TTPAL as a possible binder of a hydrophobic ligand, so its ligand specificity is an open question.
TTPAL is predicted to bind phosphatidylinositol bisphosphate, which makes it relevant to work on protein interactions with membrane phosphoinositides.
With limited functional annotation and several former names, TTPAL is a useful subject for studies that aim to assign function to poorly understood genes.
UniProt states that TTPAL may act as a protein that binds a hydrophobic ligand. The NCBI Gene summary adds that it is predicted to enable phosphatidylinositol bisphosphate binding and is located in the membrane. Its exact biological role has not been defined in these sources.
TTPAL stands for alpha tocopherol transfer protein like. Its aliases and previous symbols are dJ179M20.3 and C20orf121, and earlier names include chromosome 20 open reading frame 121 and tocopherol (alpha) transfer protein-like. UniProt lists the protein as Alpha-tocopherol transfer protein-like.
A mouse ortholog named Ttpal is recorded for the human gene, which supports comparative work between human and mouse. No rat ortholog is given in the data used here. Check the datasheet of any product for its validated reactivity.
Other CRAL-TRIO domain proteins and tocopherol-related lipid-binding targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BTX7; product specifications from Assay Genie datasheets.