LAYN
LAYN (layilin) is a membrane protein that acts as a receptor for hyaluronate, also known as hyaluronic acid. The gene, previously listed under the symbols FLJ30977 and FLJ31092, belongs to the C-type lectin domain containing group. Browse Assay Genie's current range of LAYN research reagents below, or read on for the biology behind the target.
LAYN, or layilin, is annotated in UniProt as a receptor for hyaluronate. Consistent with this, NCBI Gene reports that it enables hyaluronic acid binding activity. Hyaluronic acid is therefore the ligand most clearly associated with the protein, and LAYN is studied in the context of how cells interact with this polysaccharide at the cell surface.
UniProt lists the subcellular location of layilin as membrane, and NCBI Gene describes the protein as located in focal adhesion. Focal adhesions are the sites where cells attach to their surroundings, which places LAYN at the interface between the cell and its extracellular environment. The human protein is encoded by the LAYN gene, and a mouse ortholog, Layn, is recorded.
In HGNC, the LAYN gene is approved under the name layilin and assigned to the C-type lectin domain containing gene group. The aliases FLJ30977 and FLJ31092 appear in the literature and databases as earlier designations for the same gene. Researchers working with layilin may find these alternative names useful when searching across older records.
LAYN is annotated as a hyaluronate receptor, making it a relevant target for work on hyaluronic acid recognition at the cell surface.
NCBI Gene places layilin in focal adhesions, so it is of interest when examining the molecular composition of cell attachment sites.
As a member of the C-type lectin domain containing group, LAYN provides a point of comparison with other proteins sharing this domain type.
Layilin is a membrane-associated receptor, supporting studies of how extracellular polysaccharide ligands are sensed at the plasma membrane.
UniProt annotates layilin as a receptor for hyaluronate, and NCBI Gene states that it enables hyaluronic acid binding activity. It is a membrane protein that is located in focal adhesions, linking hyaluronic acid recognition to sites of cell attachment.
The HGNC-approved name is layilin, and UniProt uses the protein name Layilin. The gene has also been listed under the aliases FLJ30977 and FLJ31092. Searching with any of these names can help locate older records for the same gene.
A mouse ortholog, Layn, is recorded for the human LAYN gene. No rat ortholog is given in the data used here. Check the datasheet of any product for its validated reactivity before choosing a reagent for a particular species.
Hyaluronate-binding proteins, C-type lectin domain proteins and focal adhesion components studied alongside layilin.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6UX15; product specifications from Assay Genie datasheets.