C7orf50
C7orf50, now named cholesin (CHLSN), is a hormone secreted from the intestine in response to cholesterol. It acts on the liver to inhibit cholesterol synthesis and very low-density lipoprotein (VLDL) secretion, lowering circulating cholesterol. Browse Assay Genie's current range of C7orf50 research reagents below, or read on for the biology behind the target.
C7orf50 encodes cholesin, a hormone released from the intestine in response to cholesterol. Once secreted, it acts at a distance on the liver, where it inhibits cholesterol synthesis and suppresses VLDL secretion. The net effect is a reduction in circulating cholesterol levels, placing cholesin within an intestine-to-liver signalling axis that responds to cholesterol.
Cholesin acts by binding to its receptor, GPR146. Consistent with this endocrine role, UniProt annotates the protein as secreted, and the NCBI Gene summary describes it as enabling hormone activity, being involved in negative regulation of the cholesterol biosynthetic process and being active in the extracellular space. The human C7orf50 gene is found at 7p22.3 and is listed by HGNC in the group of microRNA protein coding host genes. Orthologues are annotated in mouse and rat as Chlsn, which allows the pathway to be studied in rodent models.
The gene has been known under several names, including chromosome 7 open reading frame 50 (C7orf50), MGC11257 and YCR016W, before the HGNC-approved name cholesin and symbol CHLSN were adopted. Researchers may encounter any of these names in the literature when searching for work on the cholesin protein or the C7orf50 gene, particularly in studies of cholesterol homeostasis and lipoprotein metabolism.
Cholesin lowers circulating cholesterol by inhibiting hepatic cholesterol synthesis, making it a focus for studies of how cholesterol levels are regulated.
Secreted from the intestine in response to cholesterol, cholesin provides a model for communication between intestine and liver.
Cholesin inhibits VLDL secretion, so it is relevant to research on how lipoprotein output from the liver is controlled.
Cholesin signals by binding GPR146, supporting investigation of this receptor and the pathway through which the hormone acts.
C7orf50, or cholesin, is a hormone secreted from the intestine in response to cholesterol. It acts on the liver to inhibit cholesterol synthesis and VLDL secretion, reducing circulating cholesterol. It signals by binding its receptor, GPR146.
The HGNC-approved name is cholesin, with the symbol CHLSN. Earlier designations include chromosome 7 open reading frame 50 (C7orf50), MGC11257 and YCR016W. UniProt lists the protein as Protein cholesin, so all of these names may appear in publications and databases.
Yes. Orthologues of the human gene are annotated in both mouse and rat, and each is named Chlsn. This makes rodent systems a practical route for studying cholesin biology. Check the datasheet of any product for its validated reactivity.
Receptor partners and cholesterol-metabolism targets related to cholesin signalling, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BRJ6; product specifications from Assay Genie datasheets.