CANT1
CANT1 (calcium activated nucleotidase 1) is a calcium-dependent nucleotidase of the apyrase family that preferentially hydrolyses UDP, GDP and IDP. It is also known as SHAPY and SCAN-1, and is involved in proteoglycan synthesis. Browse Assay Genie's current range of CANT1 research reagents below, or read on for the biology behind the target.
CANT1 is a calcium-dependent nucleotidase with a preference for the ribonucleoside diphosphates UDP, GDP and IDP. Its activity towards ADP and CDP is very low. In vitro, it can also act on the ribonucleoside triphosphates UTP, GTP, ITP, ATP and CTP, but with low or negligible efficiency. It does not hydrolyse AMP or GMP. The enzyme is classified under EC 3.6.1.6 and is involved in proteoglycan synthesis.
The protein, named soluble calcium-activated nucleotidase 1 in UniProt, belongs to the apyrase family. Despite the word "soluble" in its name, UniProt annotates its subcellular locations as the endoplasmic reticulum membrane, the Golgi stack membrane and the cell membrane. The mouse and rat orthologs are both designated Cant1, which makes rodent models a practical route to studying the CANT1 gene and its protein product. Alternatively spliced transcript variants have been noted for the gene.
CANT1 is also known as SHAPY and SCAN-1. Mutations in the gene are associated with Desbuquois dysplasia with hand anomalies, which links the enzyme to skeletal development research. Researchers studying nucleotide metabolism in the secretory pathway, proteoglycan biosynthesis or inherited skeletal disorders will find CANT1 a relevant target. Any CANT1 antibody, CANT1 ELISA kit or CANT1 protein reagent should be matched to the species and application of your experiment.
CANT1 is involved in proteoglycan synthesis, so it is a target for studies of how nucleotide hydrolysis supports this process.
Mutations in CANT1 are associated with Desbuquois dysplasia with hand anomalies, making it relevant to inherited skeletal disorder studies.
Its calcium dependence and preference for UDP, GDP and IDP make CANT1 a useful model for apyrase-family substrate specificity.
CANT1 localises to the endoplasmic reticulum and Golgi membranes, supporting work on nucleotide handling in the secretory pathway.
CANT1 is a calcium-dependent nucleotidase that preferentially hydrolyses the ribonucleoside diphosphates UDP, GDP and IDP, with very low activity towards ADP and CDP. It does not hydrolyse AMP or GMP. UniProt also annotates it as involved in proteoglycan synthesis.
CANT1 stands for calcium activated nucleotidase 1. Aliases are SHAPY and SCAN-1, and UniProt lists the protein as soluble calcium-activated nucleotidase 1. NCBI notes that alternatively spliced transcript variants exist for the gene. It is assigned EC 3.6.1.6.
Mouse and rat both carry a Cant1 ortholog, so rodent models can be used for functional work; check the datasheet of any product for its validated reactivity. In humans, mutations in CANT1 are associated with Desbuquois dysplasia with hand anomalies.
Other nucleotidases, apyrase-family enzymes and proteoglycan-synthesis targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WVQ1; product specifications from Assay Genie datasheets.