CHRM1
CHRM1 (cholinergic receptor muscarinic 1) is the muscarinic acetylcholine receptor M1, a G protein-coupled receptor that mediates cellular responses to acetylcholine. It acts through G proteins and its primary transducing effect is phosphoinositide turnover. Browse Assay Genie's current range of CHRM1 research reagents below, or read on for the biology behind the target.
The muscarinic acetylcholine receptor M1 mediates a range of cellular responses to acetylcholine through the action of G proteins. These include inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels. According to UniProt, the primary transducing effect of CHRM1 is phosphoinositide (Pi) turnover. The functional diversity of the muscarinic receptors is defined by acetylcholine binding.
The CHRM1 protein is found at the cell membrane, including the postsynaptic cell membrane. It belongs to the G protein-coupled receptor 1 family and the muscarinic acetylcholine receptor subfamily, within which it forms its own CHRM1 sub-subfamily. HGNC places the CHRM1 gene in the group of muscarinic cholinergic receptors, alongside related receptors such as CHRM2 and CHRM3. The mouse and rat orthologues are both named Chrm1.
Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. NCBI Gene reports that the M1 receptor is involved in mediating vagally induced bronchoconstriction and in acid secretion in the gastrointestinal tract. These roles make CHRM1 a recurring subject in studies of cholinergic signalling, and the receptor is often examined alongside the other muscarinic subtypes to separate their contributions.
CHRM1 transduces acetylcholine signals through G proteins, making it a core component for studying muscarinic receptor pathways.
Muscarinic receptors influence acetylcholine effects in the central and peripheral nervous system, and CHRM1 localises to the postsynaptic membrane.
The M1 receptor is involved in mediating vagally induced bronchoconstriction, a focus for airway research.
CHRM1 contributes to acid secretion in the gastrointestinal tract, relevant to studies of digestive regulation.
CHRM1 is a muscarinic acetylcholine receptor that signals through G proteins. Responses include adenylate cyclase inhibition, phosphoinositide breakdown and potassium channel modulation, with phosphoinositide turnover as its primary transducing effect. It contributes to vagally induced bronchoconstriction and gastric acid secretion.
The approved HGNC name is cholinergic receptor muscarinic 1, and UniProt lists the protein as muscarinic acetylcholine receptor M1. No alternative symbols or previous names are recorded in the data. NCBI Gene also refers to it as the muscarinic cholinergic receptor 1.
Yes. Mouse and rat both have a Chrm1 orthologue of the human CHRM1 gene. The receptor belongs to the muscarinic acetylcholine receptor subfamily of G protein-coupled receptors, which also includes CHRM2 and CHRM3; check the datasheet of any product for its validated reactivity.
Other muscarinic acetylcholine receptors and related G protein-coupled receptor targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P11229; product specifications from Assay Genie datasheets.