FBP2
FBP2 (fructose-bisphosphatase 2) is a gluconeogenesis regulatory enzyme that catalyses the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. It is the second isozyme of fructose-1,6-bisphosphatase, a member of the FBPase class 1 family, and was previously named fructose-1,6-bisphosphatase 2. Browse Assay Genie's current range of FBP2 research reagents below, or read on for the biology behind the target.
FBP2 catalyses the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate, a reaction that requires divalent cations. This step is a regulatory point in gluconeogenesis, the pathway that builds glucose from non-carbohydrate precursors. UniProt also notes that the enzyme probably participates in glycogen synthesis from carbohydrate precursors such as lactate, which links it to carbohydrate storage as well as glucose production.
The FBP2 gene is located at 9q22.32 and encodes the protein Fructose-1,6-bisphosphatase isozyme 2. The FBP2 protein belongs to the FBPase class 1 family and is classed by HGNC in the fructose-1,6-bisphosphatases gene group, alongside FBP1. Its enzyme activity is assigned EC 3.1.3.11. Mouse and rat each have an orthologous gene, Fbp2, which allows the enzyme to be studied in common model organisms.
UniProt records a varied subcellular distribution for FBP2: cytoplasm, nucleus, cell junction and the Z line of the sarcomere within myofibrils. This spread of locations is unusual for a metabolic enzyme and is relevant when designing localisation or fractionation experiments. HGNC lists the approved name as fructose-bisphosphatase 2, with fructose-1,6-bisphosphatase 2 as the previous name. Researchers studying FBP2 often compare it with FBP1, the other isozyme in the group, to separate the roles of each in gluconeogenic control.
FBP2 is a gluconeogenesis regulatory enzyme that hydrolyses fructose 1,6-bisphosphate to fructose 6-phosphate, making it a focus for studies of glucose production.
UniProt indicates FBP2 probably participates in glycogen synthesis from carbohydrate precursors such as lactate, an area for carbohydrate metabolism research.
As a second fructose-1,6-bisphosphatase isozyme in the same HGNC gene group, FBP2 is studied alongside FBP1 to resolve isozyme-specific roles.
FBP2 is reported in the cytoplasm, nucleus, cell junction and sarcomeric Z line, supporting work on where metabolic enzymes act within the cell.
FBP2 catalyses the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate in the presence of divalent cations. It acts as a gluconeogenesis regulatory enzyme and probably participates in glycogen synthesis from precursors such as lactate.
The HGNC approved name is fructose-bisphosphatase 2, and the previous name was fructose-1,6-bisphosphatase 2. UniProt lists the protein as Fructose-1,6-bisphosphatase isozyme 2. No alternative gene symbols are recorded, and the enzyme classification is EC 3.1.3.11.
Yes. Mouse and rat both carry an ortholog named Fbp2. Human FBP2 belongs to the FBPase class 1 family and sits in the same HGNC gene group as FBP1. Check the datasheet of any product for its validated reactivity.
The other fructose-1,6-bisphosphatase isozyme and related gluconeogenesis targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00757; product specifications from Assay Genie datasheets.