GKN1
GKN1 (gastrokine 1, also known as AMP18, CA11 and BRICD1) is a secreted protein of the gastrokine family. It has mitogenic activity and may help maintain the integrity of the gastric mucosal epithelium. Browse Assay Genie's current range of GKN1 research reagents below, or read on for the biology behind the target.
GKN1, or gastrokine 1, is annotated in UniProt as a protein with mitogenic activity that may be involved in maintaining the integrity of the gastric mucosal epithelium. The source annotation is brief, and the detailed mechanism of action of the GKN1 protein is not described in the data used for this page. The protein is found in the extracellular space as a secreted product, and UniProt also records it in cytoplasmic granules and the Golgi apparatus, consistent with a protein that passes through the secretory pathway.
The GKN1 gene encodes a 185-amino-acid protein and belongs to the gastrokine family. In the HGNC classification it is placed in the BRICHOS domain containing gene group. The protein is known by several names, including AMP18, CA11 and BRICD1, and the mouse ortholog is designated Gkn1. Researchers working with the gene or protein will often meet these alternative names in older literature.
NCBI Gene (RefSeq) notes that the protein encoded by this gene is down-regulated in human gastric cancer tissue compared with normal gastric mucosa. This observation has made GKN1 a point of interest in studies of gastric epithelial biology and gastric cancer. GKN2 is a related gastrokine that is often considered alongside it.
GKN1 is down-regulated in human gastric cancer tissue compared with normal gastric mucosa, making it a subject of interest in gastric tumour studies.
GKN1 may be involved in maintaining the integrity of the gastric mucosal epithelium, so it is relevant to studies of mucosal homeostasis.
GKN1 has mitogenic activity, which makes it relevant to work on epithelial cell growth and proliferation.
GKN1 is a secreted protein also found in cytoplasmic granules and the Golgi apparatus, relevant to studies of gastric protein secretion.
UniProt annotates GKN1 as having mitogenic activity and possibly contributing to the integrity of the gastric mucosal epithelium. It is a secreted protein of the gastrokine family. Beyond this, the source data do not describe a detailed molecular mechanism.
The HGNC-approved name is gastrokine 1, and UniProt lists the protein as Gastrokine-1. Aliases and previous symbols include AMP18, CA11 and BRICD1. The BRICD1 symbol reflects its membership of the BRICHOS domain containing gene group.
NCBI Gene reports that GKN1 protein is down-regulated in human gastric cancer tissue compared with normal gastric mucosa. A mouse ortholog, Gkn1, exists. Check the datasheet of any product for its validated reactivity.
Other gastrokine family members and gastric epithelial proteins studied alongside GKN1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NS71; product specifications from Assay Genie datasheets.