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ZKSCAN5
ZKSCAN5 (zinc finger with KRAB and SCAN domains 5) is a nuclear C2H2-type zinc finger protein of the Kruppel family that may be involved in transcriptional regulation. It is also known as ZNF914, ZSCAN37 and ZFP95. Browse Assay Genie's current range of ZKSCAN5 research reagents below, or read on for the biology behind the target.
ZKSCAN5 is annotated as a protein that may be involved in transcriptional regulation. It belongs to the Kruppel C2H2-type zinc-finger protein family and localises to the nucleus, consistent with a role in controlling gene expression. The annotation is tentative, and the precise molecular function of the protein has not been defined in the sources used here.
The ZKSCAN5 gene encodes a Kruppel-family zinc finger protein that contains a SCAN box and a KRAB A domain. In HGNC classification it sits within three groups: C2H2-type zinc fingers, SCAN domain containing and KRAB domain containing proteins. Alternative splicing of the ZKSCAN5 gene results in multiple transcript variants.
The gene symbol has changed over time. ZKSCAN5 was previously described as ZNF914, ZSCAN37 and ZFP95, and earlier names include zinc finger protein homologous to Zfp95 in mouse and zinc finger protein 95 homolog (mouse). A similar protein in mouse is differentially expressed in spermatogenesis, and the mouse ortholog is designated Zkscan5. This makes the mouse a natural system for studying how ZKSCAN5 relates to male germ cell biology.
ZKSCAN5 may be involved in transcriptional regulation, making it a candidate for studies of SCAN and KRAB domain zinc finger proteins.
As a Kruppel C2H2-type member with SCAN and KRAB A domains, ZKSCAN5 supports comparative work across related zinc finger groups.
A similar mouse protein is differentially expressed in spermatogenesis, which points to interest in ZKSCAN5 in germ cell biology.
Multiple transcript variants arise by alternative splicing, and several former symbols exist, so ZKSCAN5 is relevant to transcript and ortholog annotation studies.
ZKSCAN5 is a nuclear Kruppel-family zinc finger protein that may be involved in transcriptional regulation. It contains a SCAN box and a KRAB A domain. Beyond this putative role, its specific targets and mechanism are not described in the source annotations.
ZKSCAN5 is also known as ZNF914, ZSCAN37 and ZFP95. Earlier names refer to its similarity to mouse Zfp95. Alternative splicing of the gene produces multiple transcript variants, so researchers should consider which variant their experiment addresses.
A mouse ortholog, Zkscan5, exists, and the NCBI summary notes that a similar mouse protein is differentially expressed in spermatogenesis. Check the datasheet of any product for its validated reactivity before using it in mouse or other species.
Other KRAB and SCAN domain zinc finger proteins and transcriptional regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y2L8; product specifications from Assay Genie datasheets.
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