PMF1
PMF1 (polyamine modulated factor 1) is a component of the MIS12 kinetochore complex, which is needed for chromosome alignment and segregation during mitosis. It may also act as a cotranscription partner of NFE2L2 in polyamine-induced transcription of SSAT. Browse Assay Genie's current range of PMF1 research reagents below, or read on for the biology behind the target.
PMF1 is part of the MIS12 complex (also described as the MIS12/MIND type complex), which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Consistent with this role, the PMF1 protein is found at the kinetochore, at the centromere of chromosomes, and in the nucleoplasm. NCBI Gene lists chromosome segregation as a biological process in which it is involved.
PMF1 also has a second reported activity in transcription. UniProt notes that it may act as a cotranscription partner of NFE2L2, contributing to the regulation of polyamine-induced transcription of SSAT. In line with this, NCBI Gene describes the protein as enabling leucine zipper domain binding and transcription coactivator activity. The PMF1 gene is classed by HGNC in the MIS12 kinetochore complex gene group, and the protein is annotated as nuclear, with a kinetochore pool on the chromosome.
The name reflects its association with polyamine-modulated transcription. NCBI Gene reports that PMF1 is implicated in bladder carcinoma and urinary bladder cancer, which makes it of interest to researchers studying how defects in chromosome segregation machinery relate to disease. A mouse ortholog, Pmf1, is recorded for the gene.
PMF1 belongs to the MIS12 complex, which is required for chromosome alignment and segregation during mitosis.
As a MIS12 complex component, PMF1 contributes to kinetochore formation and is located at the centromere-associated kinetochore.
PMF1 may partner with NFE2L2 to regulate polyamine-induced transcription of SSAT, linking it to gene regulation studies.
PMF1 has been implicated in bladder carcinoma and urinary bladder cancer, making it a candidate for cancer biology studies.
PMF1 is part of the MIS12 complex, which is required for normal chromosome alignment, segregation and kinetochore formation during mitosis. UniProt also notes it may act as a cotranscription partner of NFE2L2 in polyamine-induced transcription of SSAT.
PMF1 is the approved HGNC symbol for polyamine modulated factor 1, and UniProt names the protein polyamine-modulated factor 1. No alternative aliases or previous symbols are listed in the data. HGNC places the gene in the MIS12 kinetochore complex group.
NCBI Gene reports that PMF1 is implicated in bladder carcinoma and urinary bladder cancer. A mouse ortholog, Pmf1, exists, so rodent studies are possible; check the datasheet of any product for its validated reactivity.
Related polyamine-modulated factor and kinetochore targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6P1K2; product specifications from Assay Genie datasheets.