PRR4
PRR4 (proline rich 4, also known as LPRP and PROL4) is a secreted member of the proline-rich protein family. It lacks a conserved repetitive domain and is proposed to contribute to protective functions in the eye. Browse Assay Genie's current range of PRR4 research reagents below, or read on for the biology behind the target.
PRR4 is a secreted protein belonging to the proline-rich protein family. According to the NCBI Gene summary, it differs from many relatives in that it lacks a conserved repetitive domain. The same summary indicates that the PRR4 protein may play a role in protective functions in the eye, although the detailed molecular mechanism is not described in the sources used for this page.
The PRR4 gene is located at 12p13.2 and encodes a protein of 134 amino acids with a calculated mass of about 15 kDa. Alternative splicing of the gene results in multiple transcript variants, so studies of expression at the RNA level may need to consider which variant is being measured. Read-through transcription also occurs between PRR4 and the upstream PRH1 gene (proline-rich protein HaeIII subfamily 1), which is a further point to bear in mind when designing or interpreting transcript analyses.
The gene has been known by several names. HGNC lists the aliases LPRP and PROL4, and the previous gene name, proline rich 4 (lacrimal), reflects the association of the protein with the lacrimal system. The current approved name, proline rich 4, is the one used in most recent literature, and the symbol PRR4 is the one used on this page.
Other genes with similar symbols, such as PRRG2, PRRG4 and PRRT2, share the proline-rich prefix but are separate genes, so symbol and identifier checks are worthwhile when searching databases or the literature.
PRR4 may play a role in protective functions in the eye, making it a candidate of interest for studies of ocular surface defence.
As a secreted member of the proline-rich protein family, PRR4 is relevant to work on proteins released into extracellular fluids.
Alternative splicing gives multiple PRR4 transcript variants, which is relevant to studies of isoform-specific expression and regulation.
Read-through transcription between PRR4 and the upstream PRH1 gene provides a model for studying overlapping transcription at neighbouring loci.
The NCBI Gene summary describes PRR4 as a member of the proline-rich protein family that lacks a conserved repetitive domain. It states that the protein may play a role in protective functions in the eye. UniProt lists it as secreted, but no further functional annotation is available.
PRR4 stands for proline rich 4. HGNC lists the aliases LPRP and PROL4, and the previous name was proline rich 4 (lacrimal). Alternative splicing produces multiple transcript variants of the PRR4 gene, so more than one transcript may be reported under these names.
According to the NCBI Gene summary, read-through transcription exists between PRR4 and the upstream PRH1 gene (proline-rich protein HaeIII subfamily 1). This means transcripts spanning both loci can occur, which is worth considering when interpreting PRR4 expression data.
Other proline-rich proteins and neighbouring genes related to PRR4 with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16378; product specifications from Assay Genie datasheets.