RIPK3
RIPK3 (receptor-interacting serine/threonine-protein kinase 3, also known as RIP3) is a member of the receptor-interacting protein kinase family. It is a component of the TNF receptor-I signalling complex and can induce apoptosis. Browse Assay Genie's current range of RIPK3 research reagents below, or read on for the biology behind the target.
RIPK3 is a serine/threonine protein kinase (EC 2.7.11.1) belonging to the receptor-interacting protein (RIP) family. It is a component of the tumour necrosis factor (TNF) receptor-I signalling complex, where it can induce apoptosis and weakly activate the NF-kappaB transcription factor. The UniProt annotation also links RIPK3 to necroptosis, a regulated form of cell death, and describes how a viral protein can interfere with that pathway.
The RIPK3 gene encodes a protein that contains a C-terminal domain unique among RIP family members. The protein is predominantly cytoplasmic, and UniProt records it in the cytosol and the nucleus. It can undergo nucleocytoplasmic shuttling, which depends on novel nuclear localisation and export signals. In classification terms, it belongs to the protein kinase superfamily and the TKL Ser/Thr protein kinase family. HGNC places it in the receptor interacting serine/threonine kinase family, alongside targets such as RIPK1 and RIPK2.
In herpes simplex virus 1 (HHV-1) infection, RIPK3 forms heteromeric amyloid structures with the viral protein RIR1/ICP6. These structures may inhibit RIPK3-mediated necroptosis, preventing the host cell death pathway and allowing viral evasion. This makes RIPK3 a useful reference point for studies of host-pathogen interaction and cell death signalling. The protein is also known as RIP3, and the previous HGNC name was receptor-interacting serine-threonine kinase 3. Mouse and rat both have a Ripk3 ortholog.
RIPK3-mediated necroptosis is a regulated cell death pathway, and RIPK3 is a central protein for studying how it is triggered and controlled.
RIPK3 is a component of the TNF receptor-I signalling complex, so it is relevant to studies of TNF-driven cell fate decisions.
RIPK3 can induce apoptosis and weakly activate NF-kappaB, which makes it useful for dissecting how cells balance survival and death signals.
HHV-1 ICP6 forms amyloid structures with RIPK3 that may block necroptosis, offering a model for how viruses evade host cell death.
RIPK3 is a serine/threonine kinase of the RIP family. It is a component of the TNF receptor-I signalling complex, can induce apoptosis and weakly activates NF-kappaB. UniProt also describes its role in necroptosis, which HHV-1 ICP6 may inhibit.
RIPK3 is also called RIP3, and its previous HGNC name was receptor-interacting serine-threonine kinase 3. The UniProt protein name is receptor-interacting serine/threonine-protein kinase 3. The enzyme classification is EC 2.7.11.1.
Yes. Both mouse and rat have a Ripk3 ortholog of the human gene. RIPK3 sits in the RIP kinase family alongside RIPK1 and RIPK2. Check the datasheet of any product for its validated reactivity.
Other receptor-interacting protein kinases involved in TNF receptor signalling and cell death research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y572; product specifications from Assay Genie datasheets.